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eF-site ID
|
2l0j_3-D |
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PDB Code
|
2l0j |
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Model
|
3 |
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Chain
|
D |
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click to enlarge
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Title
|
Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer |
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Classification
|
TRANSPORT PROTEIN |
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Compound
|
Matrix protein 2 |
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Source
|
null (M2_I72A2) |
|
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Sequence
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D: |
SSDPLVVAASIIGILHLILWILDRLFFKSIYRFFEHGLKR
G
|
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Description
|
(1) |
Matrix protein 2
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
23-43 |
| type |
TRANSMEM |
| sequence |
SDPLVVAASIIGILHLILWIL
|
| description |
Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
D |
| residue |
37 |
| type |
SITE |
| sequence |
H
|
| description |
Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
D |
| residue |
41 |
| type |
SITE |
| sequence |
W
|
| description |
Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
D |
| residue |
50 |
| type |
LIPID |
| sequence |
S
|
| description |
S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069
|
| source |
Swiss-Prot : SWS_FT_FI4
|
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