eF-site ID 2ksb_3-AB
PDB Code 2ksb
Model 3
Chain A, B

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Title Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R
Classification NEUROPEPTIDE RECEPTOR/NEUROPEPTIDE
Compound Substance-P receptor
Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence A:  DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTV
IVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASM
AAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIY
SMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLL
AFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVT
VLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVS
AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK
FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFR
CCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTV
VGA
B:  RPKPQQFFGLM
Description


Functional site

1) chain A
residue 118-134
type prosite
sequence ASIYSMTAVAFDRYMAI
description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIySMTAVAFDRYMaI
source prosite : PS00237

2) chain B
residue 371-375
type prosite
sequence FFGLM
description TACHYKININ Tachykinin family signature. FFGLM
source prosite : PS00267

3) chain B
residue 366
type SITE
sequence P
description Cleavage; by FAP => ECO:0000269|PubMed:21314817
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 87-106
type SITE
sequence VVNFTYAVHNEWYYGLFYCK
description Cleavage; by FAP => ECO:0000269|PubMed:21314817
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 170-194
type SITE
sequence TTETMPSRVVCMIEWPEHPNKIYEK
description Cleavage; by FAP => ECO:0000269|PubMed:21314817
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 271-283
type SITE
sequence PYINPDLYLKKFI
description Cleavage; by FAP => ECO:0000269|PubMed:21314817
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 197
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:8384323
source Swiss-Prot : SWS_FT_FI10

8) chain A
residue 322
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11

9) chain A
residue 14
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI12

10) chain A
residue 18
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI12

11) chain B
residue 370
type SITE
sequence Q
description Cleavage; by MME => ECO:0000269|PubMed:6208535
source Swiss-Prot : SWS_FT_FI2

12) chain B
residue 371
type SITE
sequence F
description Cleavage; by MME => ECO:0000269|PubMed:6208535
source Swiss-Prot : SWS_FT_FI2

13) chain B
residue 372
type SITE
sequence F
description Cleavage; by ACE => ECO:0000269|PubMed:6208535
source Swiss-Prot : SWS_FT_FI3

14) chain A
residue 129-148
type SITE
sequence DRYMAIIHPLQPRLSATATK
description Cleavage; by ACE => ECO:0000269|PubMed:6208535
source Swiss-Prot : SWS_FT_FI3

15) chain A
residue 220-248
type SITE
sequence GITLWASEIPGDSSDRYHEQVSAKRKVVK
description Cleavage; by ACE => ECO:0000269|PubMed:6208535
source Swiss-Prot : SWS_FT_FI3

16) chain B
residue 373
type SITE
sequence G
description Cleavage; by ACE and MME => ECO:0000269|PubMed:6208535
source Swiss-Prot : SWS_FT_FI4

17) chain B
residue 375
type MOD_RES
sequence M
description Methionine amide => ECO:0000269|PubMed:3770210
source Swiss-Prot : SWS_FT_FI5

18) chain A
residue 149-169
type TRANSMEM
sequence VVICVIWVLALLLAFPQGYYS
description Helical; Name=4 => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

19) chain A
residue 195-219
type TRANSMEM
sequence VYHICVTVLIYFLPLLVIGYAYTVV
description Helical; Name=5 => ECO:0000255
source Swiss-Prot : SWS_FT_FI7

20) chain A
residue 249-270
type TRANSMEM
sequence MMIVVVCTFAICWLPFHIFFLL
description Helical; Name=6 => ECO:0000255
source Swiss-Prot : SWS_FT_FI8

21) chain A
residue 284-308
type TRANSMEM
sequence QQVYLAIMWLAMSSTMYNPIIYCCL
description Helical; Name=7 => ECO:0000255
source Swiss-Prot : SWS_FT_FI9


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