eF-site ID 2ksb_3-AB PDB Code 2ksb Model 3 Chain A, B click to enlarge Title Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R Classification NEUROPEPTIDE RECEPTOR/NEUROPEPTIDE Compound Substance-P receptor Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTV IVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASM AAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIY SMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLL AFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVT VLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVS AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFR CCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTV VGA B:  RPKPQQFFGLM Description Functional site 1) chain A residue 118-134 type prosite sequence ASIYSMTAVAFDRYMAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIySMTAVAFDRYMaI source prosite : PS00237 2) chain B residue 371-375 type prosite sequence FFGLM description TACHYKININ Tachykinin family signature. FFGLM source prosite : PS00267 3) chain B residue 366 type SITE sequence P description Cleavage; by FAP => ECO:0000269|PubMed:21314817 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 87-106 type SITE sequence VVNFTYAVHNEWYYGLFYCK description Cleavage; by FAP => ECO:0000269|PubMed:21314817 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 170-194 type SITE sequence TTETMPSRVVCMIEWPEHPNKIYEK description Cleavage; by FAP => ECO:0000269|PubMed:21314817 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 271-283 type SITE sequence PYINPDLYLKKFI description Cleavage; by FAP => ECO:0000269|PubMed:21314817 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 197 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8384323 source Swiss-Prot : SWS_FT_FI10 8) chain A residue 322 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000255 source Swiss-Prot : SWS_FT_FI11 9) chain A residue 14 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI12 10) chain A residue 18 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI12 11) chain B residue 370 type SITE sequence Q description Cleavage; by MME => ECO:0000269|PubMed:6208535 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 371 type SITE sequence F description Cleavage; by MME => ECO:0000269|PubMed:6208535 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 372 type SITE sequence F description Cleavage; by ACE => ECO:0000269|PubMed:6208535 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 129-148 type SITE sequence DRYMAIIHPLQPRLSATATK description Cleavage; by ACE => ECO:0000269|PubMed:6208535 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 220-248 type SITE sequence GITLWASEIPGDSSDRYHEQVSAKRKVVK description Cleavage; by ACE => ECO:0000269|PubMed:6208535 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 373 type SITE sequence G description Cleavage; by ACE and MME => ECO:0000269|PubMed:6208535 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 375 type MOD_RES sequence M description Methionine amide => ECO:0000269|PubMed:3770210 source Swiss-Prot : SWS_FT_FI5 18) chain A residue 149-169 type TRANSMEM sequence VVICVIWVLALLLAFPQGYYS description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 19) chain A residue 195-219 type TRANSMEM sequence VYHICVTVLIYFLPLLVIGYAYTVV description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 20) chain A residue 249-270 type TRANSMEM sequence MMIVVVCTFAICWLPFHIFFLL description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 21) chain A residue 284-308 type TRANSMEM sequence QQVYLAIMWLAMSSTMYNPIIYCCL description Helical; Name=7 => ECO:0000255 source Swiss-Prot : SWS_FT_FI9

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