eF-site ID 2kft_16-AB
PDB Code 2kft
Model 16
Chain A, B

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Title NMR Solution structure of the first PHD finger domain of human Autoimmune Regulator (AIRE) in complex with Histone H3(1-20Cys) Peptide
Classification TRANSCRIPTION/PROTEIN BINDING
Compound Autoimmune regulator
Source Homo sapiens (Human) (2KFT)
Sequence A:  GSKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIP
SGTWRCSSCLQATVQE
B:  ARTKQTARKSTGGKAPRKQLC
Description


Functional site

1) chain A
residue 299
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 401
source : AC1

2) chain A
residue 301
type
sequence V
description BINDING SITE FOR RESIDUE ZN A 401
source : AC1

3) chain A
residue 302
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 401
source : AC1

4) chain A
residue 319
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 401
source : AC1

5) chain A
residue 322
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 401
source : AC1

6) chain A
residue 311
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC2

7) chain A
residue 314
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC2

8) chain A
residue 337
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC2

9) chain A
residue 340
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC2

10) chain A
residue 299-340
type prosite
sequence CAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCS
SC
description ZF_PHD_1 Zinc finger PHD-type signature. CavCrdggel.......................................IcCdg..Cpra.FHlaClspplreipsgt.................................WrCssC
source prosite : PS01359

11) chain B
residue 14-20
type prosite
sequence KAPRKQL
description HISTONE_H3_1 Histone H3 signature 1. KAPRKQL
source prosite : PS00322

12) chain A
residue 296-343
type ZN_FING
sequence EDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTW
RCSSCLQA
description PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146
source Swiss-Prot : SWS_FT_FI1


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