eF-site ID 2k86_20-A
PDB Code 2k86
Model 20
Chain A

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Title Solution Structure of FOXO3a Forkhead domain
Classification DNA BINDING PROTEIN
Compound Forkhead box protein O3
Source (FOXO3_HUMAN)
Sequence A:  GSSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMV
RCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGT
GKSSWWIINPDGGKSGKAPRRRA
Description (1)  Forkhead box protein O3


Functional site

1) chain A
residue 242
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVH4
source Swiss-Prot : SWS_FT_FI6

2) chain A
residue 206-212
type prosite
sequence WKNSIRH
description FORK_HEAD_2 Fork head domain signature 2. WKNSIRH
source prosite : PS00658

3) chain A
residue 157-251
type DNA_BIND
sequence WGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKD
KGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWII
NPDGGKSGKAPRRRA
description Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 179
type MOD_RES
sequence T
description Phosphothreonine; by AMPK => ECO:0000269|PubMed:17711846
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 209
type MOD_RES
sequence S
description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:16751106
source Swiss-Prot : SWS_FT_FI3

6) chain A
residue 215
type MOD_RES
sequence S
description Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:21329882
source Swiss-Prot : SWS_FT_FI4

7) chain A
residue 230
type MOD_RES
sequence K
description N6-methyllysine => ECO:0000269|PubMed:22820736
source Swiss-Prot : SWS_FT_FI5


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