eF-site ID 2jzw_14-AB
PDB Code 2jzw
Model 14
Chain A, B

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Title How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription
Classification VIRAL PROTEIN/DNA
Compound HIV-1 nucleocapsid protein NCp7(12-55)
Source (2JZW)
Sequence A:  NVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTE
RQAN
B:  GTCCCTGTTCGGGC
Description


Functional site

1) chain A
residue 15
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 56
source : AC1

2) chain A
residue 18
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 56
source : AC1

3) chain A
residue 23
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 56
source : AC1

4) chain A
residue 36
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 57
source : AC2

5) chain A
residue 39
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 57
source : AC2

6) chain A
residue 41
type
sequence K
description BINDING SITE FOR RESIDUE ZN A 57
source : AC2

7) chain A
residue 44
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 57
source : AC2

8) chain A
residue 45
type
sequence Q
description BINDING SITE FOR RESIDUE ZN A 57
source : AC2

9) chain A
residue 13-30
type ZN_FING
sequence VKCFNCGKEGHTARNCRA
description CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047
source Swiss-Prot : SWS_FT_FI1

10) chain A
residue 34-51
type ZN_FING
sequence KGCWKCGKEGHQMKDCTE
description CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047
source Swiss-Prot : SWS_FT_FI2

11) chain A
residue 55
type SITE
sequence N
description Cleavage; by viral protease => ECO:0000255
source Swiss-Prot : SWS_FT_FI3

12) chain A
residue 32
type MOD_RES
sequence R
description Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034
source Swiss-Prot : SWS_FT_FI4


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