eF-site ID 2jky-AB PDB Code 2jky Chain A, B click to enlarge Title SACCHAROMYCES CEREVISIAE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH GMP (GUANOSINE 5'- MONOPHOSPHATE) (TETRAGONAL CRYSTAL FORM) Classification TRANSFERASE Compound HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE Source (HPRT_YEAST) Sequence A:  DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPA RILRTFLKEPGVPTIRIFAIILSLYEDLNSVGSEVGVKVS RTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELE KDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADL PAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIE QGNDIFI B:  DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPA RILRTFLKEPGVPTIRIFAIILSLYEDLNVGVKVSRTQWI DYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAE QAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEML NDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDI FI Description (1)  HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (E.C.2.4.2.8) Functional site 1) chain A residue 69 type sequence Y description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 2) chain A residue 85 type sequence K description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 3) chain A residue 110 type sequence D description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 4) chain A residue 111 type sequence E description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 5) chain A residue 112 type sequence V description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 6) chain A residue 114 type sequence D description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 7) chain A residue 115 type sequence T description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 8) chain A residue 116 type sequence R description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 9) chain A residue 117 type sequence T description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 10) chain A residue 118 type sequence T description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 11) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 12) chain A residue 187 type sequence K description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 13) chain A residue 188 type sequence W description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 14) chain A residue 189 type sequence Y description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 15) chain A residue 191 type sequence Y description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 16) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE 5GP A 300 source : AC1 17) chain A residue 38 type sequence G description BINDING SITE FOR RESIDUE SO4 A 301 source : AC2 18) chain A residue 70 type sequence E description BINDING SITE FOR RESIDUE SO4 A 301 source : AC2 19) chain A residue 71 type sequence D description BINDING SITE FOR RESIDUE SO4 A 301 source : AC2 20) chain A residue 88 type sequence R description BINDING SITE FOR RESIDUE SO4 A 301 source : AC2 21) chain B residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 A 301 source : AC2 22) chain B residue 110 type sequence D description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 23) chain B residue 111 type sequence E description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 24) chain B residue 112 type sequence V description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 25) chain B residue 114 type sequence D description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 26) chain B residue 115 type sequence T description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 27) chain B residue 116 type sequence R description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 28) chain B residue 117 type sequence T description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 29) chain B residue 118 type sequence T description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 30) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 31) chain B residue 188 type sequence W description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 32) chain B residue 189 type sequence Y description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 33) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 34) chain B residue 194 type sequence E description BINDING SITE FOR RESIDUE 5GP B 300 source : AC4 35) chain A residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 B 301 source : AC5 36) chain B residue 37 type sequence G description BINDING SITE FOR RESIDUE SO4 B 301 source : AC5 37) chain B residue 38 type sequence G description BINDING SITE FOR RESIDUE SO4 B 301 source : AC5 38) chain A residue 114 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 114 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 110 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 159 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 188 type BINDING sequence W description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 85 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 110 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 46) chain B residue 159 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 188 type BINDING sequence W description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links