eF-site ID 2jh5-D PDB Code 2jh5 Chain D click to enlarge Title Human Thrombin Hirugen Inhibitor complex Classification HYDROLASE/HYDROLASE INHIBITOR Compound THROMBIN LIGHT CHAIN Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence D:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVIDQFG Description (1)  THROMBIN LIGHT CHAIN (E.C.3.4.21.5), THROMBIN HEAVY CHAIN (E.C.3.4.21.5), HIRUDIN IIIA Functional site 1) chain D residue 169 type sequence K description BINDING SITE FOR RESIDUE CA D 1247 source : AC1 2) chain D residue 172 type sequence T description BINDING SITE FOR RESIDUE CA D 1247 source : AC1 3) chain D residue 204 type sequence P description BINDING SITE FOR RESIDUE CA D 1247 source : AC1 4) chain D residue 221 type sequence R description BINDING SITE FOR RESIDUE NA D 1248 source : AC2 5) chain D residue 224 type sequence K description BINDING SITE FOR RESIDUE NA D 1248 source : AC2 6) chain D residue 57 type sequence H description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 7) chain D residue 60 type sequence L description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 8) chain D residue 99 type sequence L description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 9) chain D residue 189 type sequence D description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 10) chain D residue 190 type sequence A description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 11) chain D residue 191 type sequence C description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 12) chain D residue 192 type sequence E description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 13) chain D residue 213 type sequence V description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 14) chain D residue 215 type sequence W description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 15) chain D residue 216 type sequence G description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 16) chain D residue 219 type sequence G description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 17) chain D residue 220 type sequence C description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 18) chain D residue 226 type sequence G description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 19) chain D residue 227 type sequence F description BINDING SITE FOR RESIDUE 895 D 1249 source : AC3 20) chain D residue 34 type sequence F description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 21) chain D residue 40 type sequence L description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 22) chain D residue 65 type sequence L description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 23) chain D residue 73 type sequence R description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 24) chain D residue 74 type sequence T description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 25) chain D residue 75 type sequence R description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 26) chain D residue 75 type sequence R description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 27) chain D residue 76 type sequence Y description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 28) chain D residue 81 type sequence K description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 29) chain D residue 82 type sequence I description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 30) chain D residue 151 type sequence Q description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 31) chain D residue 153 type sequence S description BINDING SITE FOR CHAIN H OF HIRUDIN IIIA source : AC4 32) chain D residue 102 type MOD_RES sequence D description Sulfotyrosine => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain D residue 195 type MOD_RES sequence S description Sulfotyrosine => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 34) chain D residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 36) chain D residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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