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|
eF-site ID
|
2jgc-AB |
|
PDB Code
|
2jgc |
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Chain
|
A, B |
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click to enlarge
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Title
|
Structure of the human eIF4E homologous protein, 4EHP without ligand bound |
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Classification
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TRANSLATION |
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Compound
|
EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2 |
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Source
|
Homo sapiens (Human) (4EBP1_HUMAN) |
|
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Sequence
|
A: |
VVPGPAEHPLQYNYTFWYSRRTPGRQNIKQIGTFASVEQF
WRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGK
WIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVR
FQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEY
KTHTDGPQRLLF
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| B: |
RIIYDRKFLMECRNSPV
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
66 |
| type |
MOD_RES |
| sequence |
P
|
| description |
Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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2)
|
chain |
B |
| residue |
58 |
| type |
CROSSLNK |
| sequence |
F
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
B |
| residue |
51 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
55 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
124 |
| type |
MOD_RES |
| sequence |
W
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
174 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
112-135 |
| type |
prosite |
| sequence |
DFHLFKEGIKPMWEDDANKNGGKW
|
| description |
IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW
|
| source |
prosite : PS00813
|
|
|
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