|
eF-site ID
|
2jgc-AB |
PDB Code
|
2jgc |
Chain
|
A, B |
|
click to enlarge
|
|
Title
|
Structure of the human eIF4E homologous protein, 4EHP without ligand bound |
Classification
|
TRANSLATION |
Compound
|
EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2 |
Source
|
Homo sapiens (Human) (4EBP1_HUMAN) |
|
Sequence
|
A: |
VVPGPAEHPLQYNYTFWYSRRTPGRQNIKQIGTFASVEQF
WRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGK
WIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVR
FQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEY
KTHTDGPQRLLF
|
B: |
RIIYDRKFLMECRNSPV
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
112-135 |
type |
prosite |
sequence |
DFHLFKEGIKPMWEDDANKNGGKW
|
description |
IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW
|
source |
prosite : PS00813
|
|
2)
|
chain |
B |
residue |
51 |
type |
MOD_RES |
sequence |
R
|
description |
Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
B |
residue |
55 |
type |
MOD_RES |
sequence |
D
|
description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
A |
residue |
124 |
type |
MOD_RES |
sequence |
W
|
description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
A |
residue |
174 |
type |
MOD_RES |
sequence |
R
|
description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
B |
residue |
66 |
type |
MOD_RES |
sequence |
P
|
description |
Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
B |
residue |
58 |
type |
CROSSLNK |
sequence |
F
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|