eF-site ID 2jgb-A PDB Code 2jgb Chain A click to enlarge Title Structure of human eIF4E homologous protein 4EHP with m7GTP Classification TRANSLATION Compound EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2 Source Homo sapiens (Human) (4EBP1_HUMAN) Sequence A:  KAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQ IGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMW EDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGE EICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVL NLPPNTIMEYKTHTDSIKMPGPQRLLF Description Functional site 1) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 2) chain A residue 73 type sequence T description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 3) chain A residue 78 type sequence Y description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 4) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 5) chain A residue 123 type sequence M description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 6) chain A residue 124 type sequence W description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 7) chain A residue 125 type sequence E description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 8) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 9) chain A residue 234 type sequence F description BINDING SITE FOR RESIDUE MGT B1000 source : AC1 10) chain A residue 222 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:17289916 source Swiss-Prot : SWS_FT_FI5 11) chain A residue 222 type MOD_RES sequence K description Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 124 type MOD_RES sequence W description Phosphotyrosine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 174 type MOD_RES sequence R description Phosphotyrosine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 112-135 type prosite sequence DFHLFKEGIKPMWEDDANKNGGKW description IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW source prosite : PS00813

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