eF-site ID 2jc1-AB PDB Code 2jc1 Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB698223 Classification HYDROLASE Compound RNA-DEPENDENT RNA-POLYMERASE Source Hepatitis C virus (O39930_9HEPC) Sequence A:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDL APEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICE SAGVQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRV ASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYL FNWAVKTKLKLTPIPAWFVAGYSGGDIYH B:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDL APEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICE SAGVQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRV ASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYL FNWAVKTLTPIWFVAGYSGGDIYHS Description (1)  RNA-DEPENDENT RNA-POLYMERASE Functional site 1) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 2) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 3) chain A residue 407 type sequence S description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 4) chain A residue 410 type sequence G description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 5) chain A residue 411 type sequence N description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 6) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 7) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 8) chain A residue 446 type sequence Q description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 9) chain A residue 447 type sequence I description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 10) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 11) chain A residue 449 type sequence G description BINDING SITE FOR RESIDUE 698 A 600 source : AC1 12) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 13) chain B residue 366 type sequence C description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 14) chain B residue 368 type sequence S description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 15) chain B residue 407 type sequence S description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 16) chain B residue 410 type sequence G description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 17) chain B residue 411 type sequence N description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 18) chain B residue 414 type sequence M description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 19) chain B residue 415 type sequence Y description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 20) chain B residue 446 type sequence Q description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 21) chain B residue 448 type sequence Y description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 22) chain B residue 449 type sequence G description BINDING SITE FOR RESIDUE 698 B 600 source : AC2 23) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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