eF-site ID 2jbp-L
PDB Code 2jbp
Chain L

click to enlarge
Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)
Classification TRANSFERASE
Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2
Source (MAPK2_HUMAN)
Sequence L:  PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN
KRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV
YENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASE
IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL
TDFGFAKETTYDKSCDMWSLGVIMYILLCGYPPFYSNMKT
RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT
EFMNHPWIMQSTKVPQTPLHTSRVLKED
Description


Functional site

1) chain L
residue 70
type
sequence L
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

2) chain L
residue 72
type
sequence L
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

3) chain L
residue 73
type
sequence G
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

4) chain L
residue 93
type
sequence K
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

5) chain L
residue 139
type
sequence E
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

6) chain L
residue 140
type
sequence C
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

7) chain L
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

8) chain L
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

9) chain L
residue 193
type
sequence L
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

10) chain L
residue 206
type
sequence T
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

11) chain L
residue 207
type
sequence D
description BINDING SITE FOR RESIDUE P4O L1345
source : BC2

12) chain L
residue 186
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

13) chain L
residue 70
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

14) chain L
residue 93
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

15) chain L
residue 139
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

16) chain L
residue 328
type MOD_RES
sequence S
description Phosphoserine; by autocatalysis => ECO:0000250
source Swiss-Prot : SWS_FT_FI6

17) chain L
residue 334
type MOD_RES
sequence T
description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7


Display surface

Download
Links