eF-site ID 2jbp-K PDB Code 2jbp Chain K click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence K:  HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRT QEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYEN LYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMK SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF GFAKETDKSCDMWSLGVIMYILLCGYPPFYISPGMKTRIR MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM NHPWIMQSTKVPQTPLHTSRVLKED Description Functional site 1) chain K residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 2) chain K residue 72 type sequence L description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 3) chain K residue 73 type sequence G description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 4) chain K residue 78 type sequence V description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 5) chain K residue 91 type sequence A description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 6) chain K residue 93 type sequence K description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 7) chain K residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 8) chain K residue 140 type sequence C description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 9) chain K residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 10) chain K residue 142 type sequence D description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 11) chain K residue 191 type sequence N description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 12) chain K residue 193 type sequence L description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 13) chain K residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O K1345 source : BC1 14) chain K residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 15) chain K residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain K residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain K residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 18) chain K residue 272 type MOD_RES sequence S description Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784 source Swiss-Prot : SWS_FT_FI5 19) chain K residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 20) chain K residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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