|
|
eF-site ID
|
2jbp-J |
|
PDB Code
|
2jbp |
|
Chain
|
J |
|
click to enlarge
|
|
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Title
|
Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) |
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Classification
|
TRANSFERASE |
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Compound
|
MAP KINASE-ACTIVATED PROTEIN KINASE 2 |
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Source
|
(MAPK2_HUMAN) |
|
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Sequence
|
J: |
VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ
EKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENL
YAGRKCLLIVMECLDGGELFSRIQDRAFTEREASEIMKSI
GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF
AKETTKYDKSCDMWSLGVIMYILLCGYPPFYSEEVKMLIR
NLLKTEPTQRMTITEFMNHPWIMQS
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Description
|
|
Functional site
|
|
|
1)
|
chain |
J |
| residue |
186 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
J |
| residue |
70 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
J |
| residue |
93 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
J |
| residue |
139 |
| type |
BINDING |
| sequence |
E
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
J |
| residue |
328 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by autocatalysis => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|