eF-site ID 2jbp-I PDB Code 2jbp Chain I click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence I:  QFHVKSGLQIKKNAIIDDYKVTSQVLGLGNGKVLQIFNKR TQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL TDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL LCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKML IRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRV LKEDKERWE Description Functional site 1) chain I residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 2) chain I residue 72 type sequence L description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 3) chain I residue 91 type sequence A description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 4) chain I residue 93 type sequence K description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 5) chain I residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 6) chain I residue 140 type sequence C description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 7) chain I residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 8) chain I residue 193 type sequence L description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 9) chain I residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O I1351 source : AC9 10) chain I residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 11) chain I residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 12) chain I residue 272 type MOD_RES sequence S description Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784 source Swiss-Prot : SWS_FT_FI5 13) chain I residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 14) chain I residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 15) chain I residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain I residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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