eF-site ID 2jbp-H PDB Code 2jbp Chain H click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence H:  FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKR TQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE NLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIM KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD FGFAKETTSHYVAPEVLGPEKYDKSCDMWSLGVIMYILLC GYPPFYISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN LLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE DKE Description Functional site 1) chain H residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 2) chain H residue 72 type sequence L description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 3) chain H residue 78 type sequence V description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 4) chain H residue 91 type sequence A description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 5) chain H residue 93 type sequence K description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 6) chain H residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 7) chain H residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 8) chain H residue 142 type sequence D description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 9) chain H residue 191 type sequence N description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 10) chain H residue 193 type sequence L description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 11) chain H residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O H1347 source : AC8 12) chain H residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 13) chain H residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain H residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain H residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 16) chain H residue 272 type MOD_RES sequence S description Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784 source Swiss-Prot : SWS_FT_FI5 17) chain H residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 18) chain H residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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