eF-site ID 2jbp-G
PDB Code 2jbp
Chain G

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Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)
Classification TRANSFERASE
Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2
Source (MAPK2_HUMAN)
Sequence G:  QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNK
RTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY
ENLYAGRKCLLIVMECLDGGELFSRIQDRAFTEREASEIM
KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD
FGFAKETTSPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL
CGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI
RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL
KEDKERWE
Description


Functional site

1) chain G
residue 70
type
sequence L
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

2) chain G
residue 72
type
sequence L
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

3) chain G
residue 73
type
sequence G
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

4) chain G
residue 91
type
sequence A
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

5) chain G
residue 93
type
sequence K
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

6) chain G
residue 139
type
sequence E
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

7) chain G
residue 140
type
sequence C
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

8) chain G
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

9) chain G
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

10) chain G
residue 191
type
sequence N
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

11) chain G
residue 193
type
sequence L
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

12) chain G
residue 207
type
sequence D
description BINDING SITE FOR RESIDUE P4O G1350
source : AC7

13) chain G
residue 186
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

14) chain G
residue 70
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

15) chain G
residue 93
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

16) chain G
residue 139
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

17) chain G
residue 272
type MOD_RES
sequence S
description Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784
source Swiss-Prot : SWS_FT_FI5

18) chain G
residue 328
type MOD_RES
sequence S
description Phosphoserine; by autocatalysis => ECO:0000250
source Swiss-Prot : SWS_FT_FI6

19) chain G
residue 334
type MOD_RES
sequence T
description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7


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