eF-site ID 2jbp-F PDB Code 2jbp Chain F click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence F:  QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNK RTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILK LTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI LLCGYPPFYSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL KEDKERWE Description Functional site 1) chain F residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 2) chain F residue 72 type sequence L description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 3) chain F residue 91 type sequence A description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 4) chain F residue 93 type sequence K description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 5) chain F residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 6) chain F residue 140 type sequence C description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 7) chain F residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 8) chain F residue 191 type sequence N description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 9) chain F residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O F1350 source : AC6 10) chain F residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 11) chain F residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 12) chain F residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 13) chain F residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 14) chain F residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 15) chain F residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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