eF-site ID 2jbp-E PDB Code 2jbp Chain E click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence E:  PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN KRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV YENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASE IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL TDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL LCGYPPFYSNPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL KED Description Functional site 1) chain E residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 2) chain E residue 73 type sequence G description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 3) chain E residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 4) chain E residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 5) chain E residue 142 type sequence D description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 6) chain E residue 193 type sequence L description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 7) chain E residue 206 type sequence T description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 8) chain E residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O E1345 source : AC5 9) chain E residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 10) chain E residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 11) chain E residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 12) chain E residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 13) chain E residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain E residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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