eF-site ID 2jbp-D
PDB Code 2jbp
Chain D

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Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)
Classification TRANSFERASE
Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2
Source (MAPK2_HUMAN)
Sequence D:  HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRT
QEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYEN
LYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMK
SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF
GFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG
YPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN
LLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE
DKERWE
Description


Functional site

1) chain D
residue 70
type
sequence L
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

2) chain D
residue 72
type
sequence L
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

3) chain D
residue 73
type
sequence G
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

4) chain D
residue 93
type
sequence K
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

5) chain D
residue 139
type
sequence E
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

6) chain D
residue 140
type
sequence C
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

7) chain D
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

8) chain D
residue 142
type
sequence D
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

9) chain D
residue 193
type
sequence L
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

10) chain D
residue 207
type
sequence D
description BINDING SITE FOR RESIDUE P4O D1351
source : AC4

11) chain D
residue 186
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

12) chain D
residue 70
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

13) chain D
residue 93
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

14) chain D
residue 139
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI3

15) chain D
residue 272
type MOD_RES
sequence S
description Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784
source Swiss-Prot : SWS_FT_FI5

16) chain D
residue 328
type MOD_RES
sequence S
description Phosphoserine; by autocatalysis => ECO:0000250
source Swiss-Prot : SWS_FT_FI6

17) chain D
residue 334
type MOD_RES
sequence T
description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7


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