eF-site ID 2jbp-C PDB Code 2jbp Chain C click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence C:  FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKR TQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE NLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIM KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD FGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC GYPPFYPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLL KTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK ERWE Description Functional site 1) chain C residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 2) chain C residue 72 type sequence L description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 3) chain C residue 73 type sequence G description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 4) chain C residue 91 type sequence A description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 5) chain C residue 93 type sequence K description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 6) chain C residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 7) chain C residue 140 type sequence C description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 8) chain C residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 9) chain C residue 142 type sequence D description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 10) chain C residue 193 type sequence L description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 11) chain C residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O C1351 source : AC3 12) chain C residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 13) chain C residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain C residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain C residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 16) chain C residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 17) chain C residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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