eF-site ID 2jbp-B PDB Code 2jbp Chain B click to enlarge Title Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization) Classification TRANSFERASE Compound MAP KINASE-ACTIVATED PROTEIN KINASE 2 Source (MAPK2_HUMAN) Sequence B:  FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKR TQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL TDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL LCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKM LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSR VLKEDKERWE Description Functional site 1) chain B residue 70 type sequence L description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 2) chain B residue 72 type sequence L description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 3) chain B residue 73 type sequence G description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 4) chain B residue 91 type sequence A description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 5) chain B residue 93 type sequence K description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 6) chain B residue 139 type sequence E description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 7) chain B residue 141 type sequence L description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 8) chain B residue 193 type sequence L description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 9) chain B residue 207 type sequence D description BINDING SITE FOR RESIDUE P4O B1351 source : AC2 10) chain B residue 186 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 11) chain B residue 70 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 93 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 14) chain B residue 272 type MOD_RES sequence S description Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784 source Swiss-Prot : SWS_FT_FI5 15) chain B residue 328 type MOD_RES sequence S description Phosphoserine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 16) chain B residue 334 type MOD_RES sequence T description Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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