eF-site ID 2j91-D PDB Code 2j91 Chain D click to enlarge Title Crystal structure of Human Adenylosuccinate Lyase in complex with AMP Classification LYASE Compound ADENYLOSUCCINATE LYASE Source Homo sapiens (Human) (PUR8_HUMAN) Sequence D:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITIREMKSNLENIDFKMAAEEEKRLRHD VMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNA LDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTT VGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQAS FLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKV DIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFPYKRN PMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANR RICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQEL PFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQE GGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQV QRFLEEEVYPLLKPYE Description Functional site 1) chain D residue 111 type sequence T description BINDING SITE FOR RESIDUE CL D1001 source : AC4 2) chain D residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL D1001 source : AC4 3) chain D residue 196 type sequence R description BINDING SITE FOR RESIDUE CL D1001 source : AC4 4) chain D residue 199 type sequence K description BINDING SITE FOR RESIDUE CL D1001 source : AC4 5) chain D residue 200 type sequence G description BINDING SITE FOR RESIDUE CL D1001 source : AC4 6) chain D residue 85 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 7) chain D residue 86 type sequence H description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 8) chain D residue 87 type sequence D description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 9) chain D residue 241 type sequence Q description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 10) chain D residue 329 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 11) chain D residue 331 type sequence L description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 12) chain D residue 334 type sequence S description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 13) chain D residue 335 type sequence A description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 14) chain D residue 338 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 15) chain D residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 16) chain D residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 17) chain D residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 18) chain D residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 19) chain D residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 20) chain D residue 276 type sequence K description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 21) chain D residue 294 type sequence Y description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 22) chain D residue 295 type sequence K description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 23) chain D residue 296 type sequence R description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 24) chain D residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 26) chain D residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 27) chain D residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 28) chain D residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 29) chain D residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3 30) chain D residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 31) chain D residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 32) chain D residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 33) chain D residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 34) chain D residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 35) chain D residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6

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