eF-site ID 2j91-ABCD PDB Code 2j91 Chain A, B, C, D click to enlarge Title Crystal structure of Human Adenylosuccinate Lyase in complex with AMP Classification LYASE Compound ADENYLOSUCCINATE LYASE Source Homo sapiens (Human) (PUR8_HUMAN) Sequence A:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRL RHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYT RKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFYK RNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA NRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQ ELPFMATENIIMAMVGGSRQDCHEKIRVLSQQAASVVKQE GGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQV QRFLEEEVYPLLKPYES B:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRL RHDVMAHVHTFGHCCAAGIIHLGATSCYVGDNTDLIILRN ALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLT TVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQA SFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRK VDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFMPYK RNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA NRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQ ELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVK QEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQ QVQRFLEEEVYPLLKPYESVKAE C:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRL RHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYT RKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPYKR NPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSAN RRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQE LPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQ EGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQ VQRFLEEEVYPLLKPY D:  GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWL WLAEAEQTLGLPITIREMKSNLENIDFKMAAEEEKRLRHD VMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNA LDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTT VGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQAS FLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKV DIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFPYKRN PMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANR RICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQEL PFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQE GGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQV QRFLEEEVYPLLKPYE Description Functional site 1) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE CL A1001 source : AC1 2) chain A residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL A1001 source : AC1 3) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE CL A1001 source : AC1 4) chain A residue 199 type sequence K description BINDING SITE FOR RESIDUE CL A1001 source : AC1 5) chain A residue 200 type sequence G description BINDING SITE FOR RESIDUE CL A1001 source : AC1 6) chain B residue 111 type sequence T description BINDING SITE FOR RESIDUE CL B1001 source : AC2 7) chain B residue 196 type sequence R description BINDING SITE FOR RESIDUE CL B1001 source : AC2 8) chain B residue 199 type sequence K description BINDING SITE FOR RESIDUE CL B1001 source : AC2 9) chain B residue 200 type sequence G description BINDING SITE FOR RESIDUE CL B1001 source : AC2 10) chain C residue 111 type sequence T description BINDING SITE FOR RESIDUE CL C1001 source : AC3 11) chain C residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL C1001 source : AC3 12) chain C residue 196 type sequence R description BINDING SITE FOR RESIDUE CL C1001 source : AC3 13) chain C residue 199 type sequence K description BINDING SITE FOR RESIDUE CL C1001 source : AC3 14) chain C residue 200 type sequence G description BINDING SITE FOR RESIDUE CL C1001 source : AC3 15) chain D residue 111 type sequence T description BINDING SITE FOR RESIDUE CL D1001 source : AC4 16) chain D residue 114 type sequence Y description BINDING SITE FOR RESIDUE CL D1001 source : AC4 17) chain D residue 196 type sequence R description BINDING SITE FOR RESIDUE CL D1001 source : AC4 18) chain D residue 199 type sequence K description BINDING SITE FOR RESIDUE CL D1001 source : AC4 19) chain D residue 200 type sequence G description BINDING SITE FOR RESIDUE CL D1001 source : AC4 20) chain A residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 21) chain A residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 22) chain A residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 23) chain A residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 24) chain C residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 25) chain D residue 85 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 26) chain D residue 86 type sequence H description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 27) chain D residue 87 type sequence D description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 28) chain D residue 241 type sequence Q description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 29) chain D residue 329 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 30) chain D residue 331 type sequence L description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 31) chain D residue 334 type sequence S description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 32) chain D residue 335 type sequence A description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 33) chain D residue 338 type sequence R description BINDING SITE FOR RESIDUE AMP A1000 source : AC5 34) chain B residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 35) chain B residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 36) chain B residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 37) chain B residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 38) chain C residue 85 type sequence R description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 39) chain C residue 86 type sequence H description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 40) chain C residue 87 type sequence D description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 41) chain C residue 112 type sequence S description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 42) chain C residue 241 type sequence Q description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 43) chain C residue 329 type sequence R description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 44) chain C residue 331 type sequence L description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 45) chain C residue 334 type sequence S description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 46) chain C residue 335 type sequence A description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 47) chain C residue 338 type sequence R description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 48) chain D residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP B1000 source : AC6 49) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 50) chain B residue 85 type sequence R description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 51) chain B residue 87 type sequence D description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 52) chain B residue 241 type sequence Q description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 53) chain B residue 329 type sequence R description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 54) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 55) chain B residue 335 type sequence A description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 56) chain B residue 338 type sequence R description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 57) chain C residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 58) chain C residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 59) chain C residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 60) chain C residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP C1000 source : AC7 61) chain A residue 85 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 62) chain A residue 86 type sequence H description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 63) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 64) chain A residue 112 type sequence S description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 65) chain A residue 241 type sequence Q description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 66) chain A residue 329 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 67) chain A residue 331 type sequence L description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 68) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 69) chain A residue 335 type sequence A description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 70) chain A residue 338 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 71) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 72) chain B residue 481 type sequence E description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 73) chain D residue 20 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 74) chain D residue 21 type sequence Y description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 75) chain D residue 299 type sequence M description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 76) chain D residue 303 type sequence R description BINDING SITE FOR RESIDUE AMP D1000 source : AC8 77) chain A residue 35 type sequence K description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 78) chain A residue 39 type sequence W description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 79) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 80) chain A residue 116 type sequence G description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 81) chain A residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 82) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 83) chain A residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL A1475 source : AC9 84) chain B residue 30 type sequence F description BINDING SITE FOR RESIDUE GOL B1482 source : BC1 85) chain B residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL B1482 source : BC1 86) chain B residue 337 type sequence R description BINDING SITE FOR RESIDUE GOL B1482 source : BC1 87) chain B residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL B1482 source : BC1 88) chain B residue 341 type sequence L description BINDING SITE FOR RESIDUE GOL B1482 source : BC1 89) chain B residue 342 type sequence A description BINDING SITE FOR RESIDUE GOL B1482 source : BC1 90) chain C residue 35 type sequence K description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 91) chain C residue 39 type sequence W description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 92) chain C residue 87 type sequence D description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 93) chain C residue 116 type sequence G description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 94) chain C residue 120 type sequence D description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 95) chain C residue 334 type sequence S description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 96) chain C residue 338 type sequence R description BINDING SITE FOR RESIDUE GOL C1473 source : BC2 97) chain B residue 161 type sequence Q description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 98) chain B residue 415 type sequence K description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 99) chain D residue 276 type sequence K description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 100) chain D residue 294 type sequence Y description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 101) chain D residue 295 type sequence K description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 102) chain D residue 296 type sequence R description BINDING SITE FOR RESIDUE GOL D1474 source : BC3 103) chain A residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 104) chain B residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 105) chain C residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 106) chain D residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:22812634 source Swiss-Prot : SWS_FT_FI1 107) chain A residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 108) chain A residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 109) chain B residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 110) chain B residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 111) chain C residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 112) chain C residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 113) chain D residue 147 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 114) chain D residue 295 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 115) chain A residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 116) chain B residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 117) chain C residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 118) chain D residue 415 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI6 119) chain A residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 120) chain A residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 121) chain B residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 122) chain B residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 123) chain C residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 124) chain C residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 125) chain D residue 20 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 126) chain D residue 303 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 127) chain A residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 128) chain B residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 129) chain B residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 130) chain B residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 131) chain C residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 132) chain C residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 133) chain C residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3 134) chain C residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 135) chain C residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 136) chain C residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 137) chain D residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 138) chain A residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 139) chain D residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 140) chain D residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3 141) chain D residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 142) chain D residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 143) chain D residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 144) chain A residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3 145) chain A residue 329 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 146) chain A residue 334 type BINDING sequence S description in other chain source Swiss-Prot : SWS_FT_FI3 147) chain A residue 338 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 148) chain B residue 85 type BINDING sequence R description in other chain source Swiss-Prot : SWS_FT_FI3 149) chain B residue 111 type BINDING sequence T description in other chain source Swiss-Prot : SWS_FT_FI3 150) chain B residue 241 type BINDING sequence Q description in other chain source Swiss-Prot : SWS_FT_FI3

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