eF-site ID 2j78-AB PDB Code 2j78 Chain A, B click to enlarge Title Beta-glucosidase from Thermotoga maritima in complex with gluco- hydroximolactam Classification HYDROLASE Compound BETA-GLUCOSIDASE A Source Thermotoga maritima (BGLA_THEMA) Sequence A:  VKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTP GNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSISW PRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIYHW DLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWI TLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRAHA RAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVRFM HQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDMSE IQEKIDFVGLNYYSGHLVKFDPDAAKVSFVERDLPKTAMG WEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVSED GRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLLDN FEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNG LED B:  SNVKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSH TPGNVKNGDTGDVACDHYNRWKEDIEIIEKLGVKAYRFSI SWPRILPEGTGRVNQKGLDFYNRIIDTLLEKGITPFVTIY HWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKN WITLNEPWVVAIVGHLYGVHAPGMRDIYVAFRAVHNLLRA HARAVKVFRETVKDGKIGIVFNNGYFEPASEKEEDIRAVR FMHQFNNYPLFLNPIYRGDYPELVLEFAREYLPENYKDDM SEIQEKIDFVGLNYYSGHLVKFDPDAAKVSFVERDLPKTA MGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFDDVVS EDGRVHDQNRIDYLKAHIGQAWKAIQEGVPLKGYFVWSLL DNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKN NGL Description Functional site 1) chain A residue 66 type sequence E description BINDING SITE FOR RESIDUE CA A1447 source : AC1 2) chain A residue 69 type sequence E description BINDING SITE FOR RESIDUE CA A1447 source : AC1 3) chain B residue 138 type sequence E description BINDING SITE FOR RESIDUE CA A1447 source : AC1 4) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE CA A1447 source : AC1 5) chain A residue 278 type sequence D description BINDING SITE FOR RESIDUE CA A1448 source : AC2 6) chain A residue 281 type sequence S description BINDING SITE FOR RESIDUE CA A1448 source : AC2 7) chain A residue 54 type sequence A description BINDING SITE FOR RESIDUE ACT A1449 source : AC3 8) chain A residue 410 type sequence Y description BINDING SITE FOR RESIDUE ACT A1449 source : AC3 9) chain A residue 421 type sequence Y description BINDING SITE FOR RESIDUE ACT A1449 source : AC3 10) chain A residue 8 type sequence E description BINDING SITE FOR RESIDUE CA B1445 source : AC4 11) chain A residue 9 type sequence G description BINDING SITE FOR RESIDUE CA B1445 source : AC4 12) chain B residue 278 type sequence D description BINDING SITE FOR RESIDUE CA B1445 source : AC4 13) chain A residue 20 type sequence Q description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 14) chain A residue 121 type sequence H description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 15) chain A residue 165 type sequence N description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 16) chain A residue 166 type sequence E description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 17) chain A residue 295 type sequence Y description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 18) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 19) chain A residue 351 type sequence E description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 20) chain A residue 398 type sequence W description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 21) chain A residue 405 type sequence E description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 22) chain A residue 406 type sequence W description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 23) chain A residue 414 type sequence F description BINDING SITE FOR RESIDUE GOX A1451 source : AC6 24) chain B residue 20 type sequence Q description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 25) chain B residue 121 type sequence H description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 26) chain B residue 165 type sequence N description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 27) chain B residue 166 type sequence E description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 28) chain B residue 295 type sequence Y description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 29) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 30) chain B residue 351 type sequence E description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 31) chain B residue 398 type sequence W description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 32) chain B residue 405 type sequence E description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 33) chain B residue 406 type sequence W description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 34) chain B residue 414 type sequence F description BINDING SITE FOR RESIDUE GOX B1446 source : AC7 35) chain A residue 347-355 type prosite sequence VYITENGAA description GLYCOSYL_HYDROL_F1_1 Glycosyl hydrolases family 1 active site. VYITENGAA source prosite : PS00572 36) chain A residue 10-24 type prosite sequence FLWGVATASYQIEGS description GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FlWGvAtASYQiEgS source prosite : PS00653 37) chain A residue 166 type ACT_SITE sequence E description Proton donor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 166 type ACT_SITE sequence E description Proton donor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 351 type ACT_SITE sequence E description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10055 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 351 type ACT_SITE sequence E description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10055 source Swiss-Prot : SWS_FT_FI2

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