eF-site ID 2j50-B PDB Code 2j50 Chain B click to enlarge Title Structure of Aurora-2 in complex with PHA-739358 Classification TRANSFERASE Compound SERINE/THREONINE-PROTEIN KINASE 6 Source (STK6_HUMAN) Sequence B:  WALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVY LILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC HSKRVIHRDIKPENLLLGSAGELKIADFGWSVTLCGTLDY LPPEMIEDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLE HPWITANSSK Description (1)  SERINE/THREONINE-PROTEIN KINASE 6 (E.C.2.7.11.1) Functional site 1) chain B residue 142 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1391 source : AC2 2) chain B residue 143 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1391 source : AC2 3) chain B residue 144 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1391 source : AC2 4) chain B residue 162 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1391 source : AC2 5) chain B residue 160 type sequence A description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 6) chain B residue 162 type sequence K description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 7) chain B residue 194 type sequence L description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 8) chain B residue 211 type sequence E description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 9) chain B residue 212 type sequence Y description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 10) chain B residue 213 type sequence A description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 11) chain B residue 214 type sequence P description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 12) chain B residue 215 type sequence L description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 13) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 14) chain B residue 260 type sequence E description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 15) chain B residue 275 type sequence F description BINDING SITE FOR RESIDUE 627 B 1390 source : AC4 16) chain B residue 256 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:14580337 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 274 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 18) chain B residue 143 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 19) chain B residue 162 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 20) chain B residue 211 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 21) chain B residue 260 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 22) chain B residue 288 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:16246726, ECO:0000269|PubMed:18662907, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:26246606 source Swiss-Prot : SWS_FT_FI4 23) chain B residue 342 type MOD_RES sequence S description Phosphoserine; by PKA and PAK => ECO:0000269|PubMed:16246726 source Swiss-Prot : SWS_FT_FI5 24) chain B residue 258 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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