eF-site ID 2j3l-AB PDB Code 2j3l Chain A, B click to enlarge Title Prolyl-tRNA synthetase from Enterococcus faecalis complexed with a prolyl-adenylate analogue ('5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE) Classification LIGASE Compound PROLYL-TRNA SYNTHETASE Source Enterococcus faecalis (Streptococcus faecalis) (Q831W7_ENTFA) Sequence A:  MKQSKMLIPTLREVPNDAEVLSHQILLRAGYIRQVAAGIY SYLPLANRVLEKLKTIMREEFEKIDAVEMLMPALLPAELW KESGRYETYGPNLYRLKDRNDRDYILGPTHEETFTELIRD EINSYKRLPLNLYQIQTKYRDEKRSRSGLLRGREFIMKDG YSFHADEASLDQSYRDYEKAYSRIFERCGLEFRAIIGDGG AMGGKDSKEFMAISEIGEDTICYSTESDYAANLEMATSLY TPKKSHETQLDLEKIATPEVGTIAEVANFFEVEPQRIIKS VLFIADEEPVMVLVRGDHDVNDVKLKNFLGADFLDEATEE DARRVLGAGFGSIGPVNVSEDVKIYADLAVQDLANAIVGA NEDGYHLTNVNPDRDFQPISYEDLRFVQEGDPSPDGNGVL AFTKGIEIGHIFKLGTRYSDAMGATVLDENGREKSVIMGC YGIGVSRLLSAIVEQNADERGINWPTGIAPFDLHVVQMNV KDEYQTKLSQEVEAMMTEAGYEVLVDDRNERAGVKFADAD LIGCPIRITVGKKAVDGVVEVKIKRTGEMLEVRKEELEST LSILM B:  MKQSKMLIPTLREVPNDAEVLSHQILLRAGYIRQVAAGIY SYLPLANRVLEKLKTIMREEFEKIDAVEMLMPALLPAELW KESGRYETYGPNLYRLKDRNDRDYILGPTHEETFTELIRD EINSYKRLPLNLYQIQTKYRDEKRSRSGLLRGREFIMKDG YSFHADEASLDQSYRDYEKAYSRIFERCGLEFRAIIGDGG AMGGKDSKEFMAISEIGEDTICYSTESDYAANLEMATSLY TPKKSHETQLDLEKIATPEVGTIAEVANFFEVEPQRIIKS VLFIADEEPVMVLVRGDHDVNDVKLKNFLGADFLDEATEE DARRVLGAGFGSIGPVNVSEDVKIYADLAVQDLANAIVGA NEDGYHLTNVNPDRDFQPISYEDLRFVQEGDPSPDGNGVL AFTKGIEIGHIFKLGTRYSDAMGATVLDENGREKSVIMGC YGIGVSRLLSAIVEQNADERGINWPTGIAPFDLHVVQMNV KDEYQTKLSQEVEAMMTEAGYEVLVDDRNERAGVKFADAD LIGCPIRITVGKKAVDGVVEVKIKRTGEMLEVRKEELEST LSILMNTTSE Description (1)  PROLYL-TRNA SYNTHETASE (E.C.6.1.1.15) Functional site 1) chain A residue 272 type sequence V description BINDING SITE FOR RESIDUE SO4 A1566 source : AC1 2) chain A residue 273 type sequence E description BINDING SITE FOR RESIDUE SO4 A1566 source : AC1 3) chain A residue 276 type sequence R description BINDING SITE FOR RESIDUE SO4 A1566 source : AC1 4) chain B residue 246 type sequence H description BINDING SITE FOR RESIDUE SO4 A1566 source : AC1 5) chain A residue 151 type sequence R description BINDING SITE FOR RESIDUE SO4 A1567 source : AC2 6) chain A residue 219 type sequence D description BINDING SITE FOR RESIDUE SO4 A1567 source : AC2 7) chain A residue 447 type sequence R description BINDING SITE FOR RESIDUE SO4 A1567 source : AC2 8) chain A residue 123 type sequence N description BINDING SITE FOR RESIDUE SO4 A1568 source : AC3 9) chain A residue 124 type sequence S description BINDING SITE FOR RESIDUE SO4 A1568 source : AC3 10) chain A residue 127 type sequence R description BINDING SITE FOR RESIDUE SO4 A1568 source : AC3 11) chain A residue 88 type sequence T description BINDING SITE FOR RESIDUE SO4 A1569 source : AC4 12) chain A residue 203 type sequence G description BINDING SITE FOR RESIDUE SO4 A1569 source : AC4 13) chain A residue 417 type sequence R description BINDING SITE FOR RESIDUE SO4 A1569 source : AC4 14) chain A residue 262 type sequence T description BINDING SITE FOR RESIDUE SO4 A1570 source : AC5 15) chain A residue 263 type sequence I description BINDING SITE FOR RESIDUE SO4 A1570 source : AC5 16) chain A residue 243 type sequence K description BINDING SITE FOR RESIDUE SO4 A1571 source : AC6 17) chain A residue 295 type sequence R description BINDING SITE FOR RESIDUE SO4 A1571 source : AC6 18) chain A residue 244 type sequence K description BINDING SITE FOR RESIDUE SO4 A1572 source : AC7 19) chain A residue 246 type sequence H description BINDING SITE FOR RESIDUE SO4 A1572 source : AC7 20) chain A residue 247 type sequence E description BINDING SITE FOR RESIDUE SO4 A1572 source : AC7 21) chain B residue 245 type sequence S description BINDING SITE FOR RESIDUE SO4 A1572 source : AC7 22) chain B residue 246 type sequence H description BINDING SITE FOR RESIDUE SO4 A1572 source : AC7 23) chain A residue 193 type sequence R description BINDING SITE FOR RESIDUE SO4 A1573 source : AC8 24) chain A residue 194 type sequence A description BINDING SITE FOR RESIDUE SO4 A1573 source : AC8 25) chain A residue 205 type sequence K description BINDING SITE FOR RESIDUE SO4 A1574 source : AC9 26) chain A residue 420 type sequence D description BINDING SITE FOR RESIDUE SO4 A1574 source : AC9 27) chain A residue 434 type sequence K description BINDING SITE FOR RESIDUE SO4 A1574 source : AC9 28) chain A residue 435 type sequence S description BINDING SITE FOR RESIDUE SO4 A1574 source : AC9 29) chain A residue 99 type sequence R description BINDING SITE FOR RESIDUE SO4 A1575 source : BC1 30) chain B residue 262 type sequence T description BINDING SITE FOR RESIDUE SO4 B1571 source : BC2 31) chain B residue 263 type sequence I description BINDING SITE FOR RESIDUE SO4 B1571 source : BC2 32) chain B residue 279 type sequence K description BINDING SITE FOR RESIDUE SO4 B1571 source : BC2 33) chain A residue 244 type sequence K description BINDING SITE FOR RESIDUE SO4 B1572 source : BC3 34) chain A residue 246 type sequence H description BINDING SITE FOR RESIDUE SO4 B1572 source : BC3 35) chain B residue 272 type sequence V description BINDING SITE FOR RESIDUE SO4 B1572 source : BC3 36) chain B residue 273 type sequence E description BINDING SITE FOR RESIDUE SO4 B1572 source : BC3 37) chain B residue 276 type sequence R description BINDING SITE FOR RESIDUE SO4 B1572 source : BC3 38) chain B residue 151 type sequence R description BINDING SITE FOR RESIDUE SO4 B1573 source : BC4 39) chain B residue 218 type sequence E description BINDING SITE FOR RESIDUE SO4 B1573 source : BC4 40) chain B residue 219 type sequence D description BINDING SITE FOR RESIDUE SO4 B1573 source : BC4 41) chain B residue 447 type sequence R description BINDING SITE FOR RESIDUE SO4 B1573 source : BC4 42) chain B residue 122 type sequence I description BINDING SITE FOR RESIDUE SO4 B1574 source : BC5 43) chain B residue 123 type sequence N description BINDING SITE FOR RESIDUE SO4 B1574 source : BC5 44) chain B residue 124 type sequence S description BINDING SITE FOR RESIDUE SO4 B1574 source : BC5 45) chain B residue 127 type sequence R description BINDING SITE FOR RESIDUE SO4 B1574 source : BC5 46) chain B residue 88 type sequence T description BINDING SITE FOR RESIDUE SO4 B1575 source : BC6 47) chain B residue 203 type sequence G description BINDING SITE FOR RESIDUE SO4 B1575 source : BC6 48) chain B residue 417 type sequence R description BINDING SITE FOR RESIDUE SO4 B1575 source : BC6 49) chain A residue 324 type sequence R description BINDING SITE FOR RESIDUE SO4 B1576 source : BC7 50) chain B residue 166 type sequence D description BINDING SITE FOR RESIDUE SO4 B1576 source : BC7 51) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE SO4 B1576 source : BC7 52) chain B residue 434 type sequence K description BINDING SITE FOR RESIDUE SO4 B1576 source : BC7 53) chain B residue 193 type sequence R description BINDING SITE FOR RESIDUE SO4 B1577 source : BC8 54) chain B residue 194 type sequence A description BINDING SITE FOR RESIDUE SO4 B1577 source : BC8 55) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE SO4 B1578 source : BC9 56) chain B residue 205 type sequence K description BINDING SITE FOR RESIDUE SO4 B1578 source : BC9 57) chain B residue 415 type sequence G description BINDING SITE FOR RESIDUE SO4 B1578 source : BC9 58) chain B residue 416 type sequence T description BINDING SITE FOR RESIDUE SO4 B1578 source : BC9 59) chain B residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 B1579 source : CC1 60) chain B residue 502 type sequence E description BINDING SITE FOR RESIDUE SO4 B1579 source : CC1 61) chain B residue 144 type sequence R description BINDING SITE FOR RESIDUE SO4 B1580 source : CC2 62) chain B residue 151 type sequence R description BINDING SITE FOR RESIDUE SO4 B1580 source : CC2 63) chain B residue 243 type sequence K description BINDING SITE FOR RESIDUE SO4 B1581 source : CC3 64) chain B residue 295 type sequence R description BINDING SITE FOR RESIDUE SO4 B1581 source : CC3 65) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 66) chain A residue 111 type sequence E description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 67) chain A residue 140 type sequence R description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 68) chain A residue 142 type sequence E description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 69) chain A residue 152 type sequence G description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 70) chain A residue 155 type sequence F description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 71) chain A residue 157 type sequence M description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 72) chain A residue 159 type sequence D description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 73) chain A residue 161 type sequence Y description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 74) chain A residue 407 type sequence E description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 75) chain A residue 408 type sequence I description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 76) chain A residue 409 type sequence G description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 77) chain A residue 410 type sequence H description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 78) chain A residue 412 type sequence F description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 79) chain A residue 441 type sequence Y description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 80) chain A residue 442 type sequence G description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 81) chain A residue 444 type sequence G description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 82) chain A residue 447 type sequence R description BINDING SITE FOR RESIDUE P5A A1576 source : CC4 83) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 84) chain B residue 111 type sequence E description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 85) chain B residue 140 type sequence R description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 86) chain B residue 142 type sequence E description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 87) chain B residue 152 type sequence G description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 88) chain B residue 155 type sequence F description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 89) chain B residue 157 type sequence M description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 90) chain B residue 159 type sequence D description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 91) chain B residue 161 type sequence Y description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 92) chain B residue 202 type sequence M description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 93) chain B residue 407 type sequence E description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 94) chain B residue 408 type sequence I description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 95) chain B residue 409 type sequence G description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 96) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 97) chain B residue 412 type sequence F description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 98) chain B residue 441 type sequence Y description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 99) chain B residue 442 type sequence G description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 100) chain B residue 444 type sequence G description BINDING SITE FOR RESIDUE P5A B1582 source : CC5 101) chain B residue 447 type sequence R description BINDING SITE FOR RESIDUE P5A B1582 source : CC5

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