eF-site ID 2j27-B PDB Code 2j27 Chain B click to enlarge Title The functional role of the conserved active site proline of triosephosphate isomerase Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL Source (TPIS_TRYBB) Sequence B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEAVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description Functional site 1) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 2) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 3) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 4) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 5) chain B residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 6) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 7) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 8) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 9) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 10) chain B residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA B 702 source : AC2 11) chain B residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 B 801 source : AC3 12) chain B residue 33 type sequence I description BINDING SITE FOR RESIDUE SO4 B 801 source : AC3 13) chain B residue 34 type sequence N description BINDING SITE FOR RESIDUE SO4 B 801 source : AC3 14) chain B residue 35 type sequence H description BINDING SITE FOR RESIDUE SO4 B 801 source : AC3 15) chain B residue 247 type sequence K description BINDING SITE FOR RESIDUE SO4 B 801 source : AC3 16) chain B residue 250 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 801 source : AC3 17) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 18) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 19) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 20) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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