eF-site ID 2izz-A
PDB Code 2izz
Chain A

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Title Crystal structure of human pyrroline-5-carboxylate reductase
Classification OXIDOREDUCTASE
Compound PYRROLINE-5-CARBOXYLATE REDUCTASE 1
Source Homo sapiens (Human) (P5CR1_HUMAN)
Sequence A:  SMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDL
ATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFIL
DEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR
CMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFC
TEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPR
RLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATI
HALHVLESGGFRSLLINAVEASCIRTRELQSM
Description


Functional site

1) chain A
residue 6
type
sequence I
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

2) chain A
residue 7
type
sequence G
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

3) chain A
residue 8
type
sequence A
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

4) chain A
residue 9
type
sequence G
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

5) chain A
residue 10
type
sequence Q
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

6) chain A
residue 11
type
sequence L
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

7) chain A
residue 33
type
sequence S
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

8) chain A
residue 34
type
sequence S
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

9) chain A
residue 35
type
sequence P
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

10) chain A
residue 39
type
sequence L
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

11) chain A
residue 56
type
sequence N
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

12) chain A
residue 69
type
sequence A
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

13) chain A
residue 70
type
sequence V
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

14) chain A
residue 71
type
sequence K
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

15) chain A
residue 72
type
sequence P
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

16) chain A
residue 78
type
sequence I
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

17) chain A
residue 95
type
sequence C
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

18) chain A
residue 96
type
sequence A
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

19) chain A
residue 97
type
sequence A
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

20) chain A
residue 121
type
sequence M
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

21) chain A
residue 122
type
sequence T
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

22) chain A
residue 124
type
sequence T
description BINDING SITE FOR RESIDUE NAD A 350
source : AC1

23) chain A
residue 231
type
sequence V
description BINDING SITE FOR RESIDUE EDO A1272
source : AC2

24) chain A
residue 238
type
sequence T
description BINDING SITE FOR RESIDUE EDO A1272
source : AC2

25) chain A
residue 175
type
sequence G
description BINDING SITE FOR RESIDUE EDO A1273
source : AC3

26) chain A
residue 230
type
sequence N
description BINDING SITE FOR RESIDUE EDO A1274
source : AC4

27) chain A
residue 233
type
sequence S
description BINDING SITE FOR RESIDUE EDO A1274
source : AC4

28) chain A
residue 230
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 350
source : AC5

29) chain A
residue 231
type
sequence V
description BINDING SITE FOR RESIDUE NAD B 350
source : AC5

30) chain A
residue 6
type BINDING
sequence I
description BINDING => ECO:0000269|Ref.18
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 34
type BINDING
sequence S
description BINDING => ECO:0000269|Ref.18
source Swiss-Prot : SWS_FT_FI1

32) chain A
residue 56
type BINDING
sequence N
description BINDING => ECO:0000269|Ref.18
source Swiss-Prot : SWS_FT_FI1

33) chain A
residue 69
type BINDING
sequence A
description BINDING => ECO:0000269|Ref.18
source Swiss-Prot : SWS_FT_FI1

34) chain A
residue 95
type BINDING
sequence C
description BINDING => ECO:0000269|Ref.18
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 2
type MOD_RES
sequence S
description N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330
source Swiss-Prot : SWS_FT_FI2

36) chain A
residue 224-246
type prosite
sequence PGQLKDNVSSPGGATIHALHVLE
description P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkdnVSSpGGaTihALhvLE
source prosite : PS00521


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