eF-site ID 2izz-ABCDE PDB Code 2izz Chain A, B, C, D, E click to enlarge Title Crystal structure of human pyrroline-5-carboxylate reductase Classification OXIDOREDUCTASE Compound PYRROLINE-5-CARBOXYLATE REDUCTASE 1 Source Homo sapiens (Human) (P5CR1_HUMAN) Sequence A:  SMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDL ATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFIL DEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR CMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFC TEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPR RLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATI HALHVLESGGFRSLLINAVEASCIRTRELQSM B:  NLYFQSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASS PDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHI IPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPA PRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLS SVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVK MGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSP GGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMAD C:  SMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDL ATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFIL DEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR CMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFC TEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPR RLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATI HALHVLESGGFRSLLINAVEASCIRTRELQSMADQE D:  LYFQSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSP DMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHII PFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAP RVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSS VGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKM GLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPG GATIHALHVLESGGFRSLLINAVEASCIRTRELQSM E:  MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLA TVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILD EIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCT EVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRR LAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH ALHVLESGGFRSLLINAVEASCIRTRELQSMA Description Functional site 1) chain A residue 6 type sequence I description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 2) chain A residue 7 type sequence G description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 3) chain A residue 8 type sequence A description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 4) chain A residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 5) chain A residue 10 type sequence Q description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 6) chain A residue 11 type sequence L description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 7) chain A residue 33 type sequence S description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 8) chain A residue 34 type sequence S description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 9) chain A residue 35 type sequence P description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 10) chain A residue 39 type sequence L description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 11) chain A residue 56 type sequence N description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 12) chain A residue 69 type sequence A description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 13) chain A residue 70 type sequence V description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 14) chain A residue 71 type sequence K description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 15) chain A residue 72 type sequence P description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 16) chain A residue 78 type sequence I description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 17) chain A residue 95 type sequence C description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 18) chain A residue 96 type sequence A description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 19) chain A residue 97 type sequence A description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 20) chain A residue 121 type sequence M description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 21) chain A residue 122 type sequence T description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 22) chain A residue 124 type sequence T description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 23) chain B residue 230 type sequence N description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 24) chain B residue 231 type sequence V description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 25) chain B residue 233 type sequence S description BINDING SITE FOR RESIDUE NAD A 350 source : AC1 26) chain A residue 231 type sequence V description BINDING SITE FOR RESIDUE EDO A1272 source : AC2 27) chain A residue 238 type sequence T description BINDING SITE FOR RESIDUE EDO A1272 source : AC2 28) chain B residue 175 type sequence G description BINDING SITE FOR RESIDUE EDO A1272 source : AC2 29) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE EDO A1273 source : AC3 30) chain B residue 231 type sequence V description BINDING SITE FOR RESIDUE EDO A1273 source : AC3 31) chain B residue 238 type sequence T description BINDING SITE FOR RESIDUE EDO A1273 source : AC3 32) chain A residue 230 type sequence N description BINDING SITE FOR RESIDUE EDO A1274 source : AC4 33) chain A residue 233 type sequence S description BINDING SITE FOR RESIDUE EDO A1274 source : AC4 34) chain B residue 71 type sequence K description BINDING SITE FOR RESIDUE EDO A1274 source : AC4 35) chain A residue 230 type sequence N description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 36) chain A residue 231 type sequence V description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 37) chain B residue 7 type sequence G description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 38) chain B residue 8 type sequence A description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 39) chain B residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 40) chain B residue 10 type sequence Q description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 41) chain B residue 11 type sequence L description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 42) chain B residue 34 type sequence S description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 43) chain B residue 35 type sequence P description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 44) chain B residue 39 type sequence L description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 45) chain B residue 56 type sequence N description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 46) chain B residue 69 type sequence A description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 47) chain B residue 70 type sequence V description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 48) chain B residue 71 type sequence K description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 49) chain B residue 72 type sequence P description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 50) chain B residue 78 type sequence I description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 51) chain B residue 95 type sequence C description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 52) chain B residue 96 type sequence A description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 53) chain B residue 97 type sequence A description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 54) chain B residue 121 type sequence M description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 55) chain B residue 122 type sequence T description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 56) chain B residue 124 type sequence T description BINDING SITE FOR RESIDUE NAD B 350 source : AC5 57) chain C residue 6 type sequence I description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 58) chain C residue 7 type sequence G description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 59) chain C residue 8 type sequence A description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 60) chain C residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 61) chain C residue 10 type sequence Q description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 62) chain C residue 11 type sequence L description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 63) chain C residue 34 type sequence S description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 64) chain C residue 35 type sequence P description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 65) chain C residue 56 type sequence N description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 66) chain C residue 69 type sequence A description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 67) chain C residue 70 type sequence V description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 68) chain C residue 71 type sequence K description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 69) chain C residue 72 type sequence P description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 70) chain C residue 78 type sequence I description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 71) chain C residue 95 type sequence C description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 72) chain C residue 96 type sequence A description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 73) chain C residue 97 type sequence A description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 74) chain C residue 122 type sequence T description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 75) chain C residue 124 type sequence T description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 76) chain D residue 230 type sequence N description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 77) chain D residue 231 type sequence V description BINDING SITE FOR RESIDUE NAD C 350 source : AC6 78) chain C residue 231 type sequence V description BINDING SITE FOR RESIDUE EDO C1276 source : AC7 79) chain C residue 233 type sequence S description BINDING SITE FOR RESIDUE EDO C1276 source : AC7 80) chain C residue 238 type sequence T description BINDING SITE FOR RESIDUE EDO C1276 source : AC7 81) chain C residue 97 type sequence A description BINDING SITE FOR RESIDUE EDO C1277 source : AC8 82) chain C residue 171 type sequence T description BINDING SITE FOR RESIDUE EDO C1277 source : AC8 83) chain C residue 175 type sequence G description BINDING SITE FOR RESIDUE EDO C1277 source : AC8 84) chain D residue 231 type sequence V description BINDING SITE FOR RESIDUE EDO C1277 source : AC8 85) chain D residue 238 type sequence T description BINDING SITE FOR RESIDUE EDO C1277 source : AC8 86) chain C residue 230 type sequence N description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 87) chain C residue 231 type sequence V description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 88) chain C residue 233 type sequence S description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 89) chain D residue 8 type sequence A description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 90) chain D residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 91) chain D residue 10 type sequence Q description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 92) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 93) chain D residue 33 type sequence S description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 94) chain D residue 34 type sequence S description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 95) chain D residue 35 type sequence P description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 96) chain D residue 39 type sequence L description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 97) chain D residue 56 type sequence N description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 98) chain D residue 69 type sequence A description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 99) chain D residue 70 type sequence V description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 100) chain D residue 71 type sequence K description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 101) chain D residue 72 type sequence P description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 102) chain D residue 95 type sequence C description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 103) chain D residue 96 type sequence A description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 104) chain D residue 97 type sequence A description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 105) chain D residue 122 type sequence T description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 106) chain D residue 124 type sequence T description BINDING SITE FOR RESIDUE NAD D 350 source : AC9 107) chain D residue 230 type sequence N description BINDING SITE FOR RESIDUE EDO D1272 source : BC1 108) chain D residue 233 type sequence S description BINDING SITE FOR RESIDUE EDO D1272 source : BC1 109) chain E residue 7 type sequence G description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 110) chain E residue 8 type sequence A description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 111) chain E residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 112) chain E residue 10 type sequence Q description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 113) chain E residue 11 type sequence L description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 114) chain E residue 34 type sequence S description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 115) chain E residue 35 type sequence P description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 116) chain E residue 39 type sequence L description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 117) chain E residue 56 type sequence N description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 118) chain E residue 69 type sequence A description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 119) chain E residue 70 type sequence V description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 120) chain E residue 71 type sequence K description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 121) chain E residue 72 type sequence P description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 122) chain E residue 95 type sequence C description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 123) chain E residue 96 type sequence A description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 124) chain E residue 97 type sequence A description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 125) chain E residue 122 type sequence T description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 126) chain E residue 124 type sequence T description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 127) chain E residue 231 type sequence V description BINDING SITE FOR RESIDUE NAD E 350 source : BC2 128) chain E residue 71 type sequence K description BINDING SITE FOR RESIDUE EDO E1273 source : BC3 129) chain E residue 230 type sequence N description BINDING SITE FOR RESIDUE EDO E1273 source : BC3 130) chain E residue 233 type sequence S description BINDING SITE FOR RESIDUE EDO E1273 source : BC3 131) chain A residue 6 type BINDING sequence I description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 132) chain B residue 95 type BINDING sequence C description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 133) chain C residue 6 type BINDING sequence I description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 134) chain C residue 34 type BINDING sequence S description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 135) chain C residue 56 type BINDING sequence N description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 136) chain C residue 69 type BINDING sequence A description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 137) chain C residue 95 type BINDING sequence C description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 138) chain D residue 6 type BINDING sequence I description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 139) chain D residue 34 type BINDING sequence S description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 140) chain D residue 56 type BINDING sequence N description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 141) chain D residue 69 type BINDING sequence A description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 142) chain A residue 34 type BINDING sequence S description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 143) chain D residue 95 type BINDING sequence C description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 144) chain E residue 6 type BINDING sequence I description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 145) chain E residue 34 type BINDING sequence S description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 146) chain E residue 56 type BINDING sequence N description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 147) chain E residue 69 type BINDING sequence A description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 148) chain E residue 95 type BINDING sequence C description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 149) chain A residue 56 type BINDING sequence N description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 150) chain A residue 69 type BINDING sequence A description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 151) chain A residue 95 type BINDING sequence C description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 152) chain B residue 6 type BINDING sequence I description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 153) chain B residue 34 type BINDING sequence S description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 154) chain B residue 56 type BINDING sequence N description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 155) chain B residue 69 type BINDING sequence A description BINDING => ECO:0000269|Ref.18 source Swiss-Prot : SWS_FT_FI1 156) chain A residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 source Swiss-Prot : SWS_FT_FI2 157) chain B residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 source Swiss-Prot : SWS_FT_FI2 158) chain C residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 source Swiss-Prot : SWS_FT_FI2 159) chain D residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 source Swiss-Prot : SWS_FT_FI2 160) chain E residue 2 type MOD_RES sequence S description N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 source Swiss-Prot : SWS_FT_FI2 161) chain A residue 224-246 type prosite sequence PGQLKDNVSSPGGATIHALHVLE description P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkdnVSSpGGaTihALhvLE source prosite : PS00521

Display surface Download Links