eF-site ID 2iya-A
PDB Code 2iya
Chain A

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Title The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering
Classification TRANSFERASE
Compound OLEANDOMYCIN GLYCOSYLTRANSFERASE
Source Streptomyces antibioticus (Q3HTL7_STRAT)
Sequence A:  TPRHISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITDE
FAAQVKAAGATPVVYDSILPKESNPEESWPEDQESAMGLF
LDEAVRVLPQLEDAYADDRPDLIVYDIASWPAPVLGRKWD
IPFVQLSPTFVAYEGFEEDVPAVQDPTAEDGLVRFFTRLS
AFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDN
YTFVGPTYGDRSHQGTWEGPGDGRPVLLIALGSAFTDHLD
FYRTCLSAVDGLDWHVVLSVGRFVDPADLGEVPPNVEVHQ
WVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIA
EQTMNAERIVELGLGRHIPRDQVTAEKLREAVLAVASDPG
VAERLAAVRQEIREAGGARAAADILEGILAEA
Description (1)  OLEANDOMYCIN GLYCOSYLTRANSFERASE (E.C.2.4.1.-)


Functional site

1) chain A
residue 24
type
sequence G
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

2) chain A
residue 27
type
sequence N
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

3) chain A
residue 242
type
sequence R
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

4) chain A
residue 245
type
sequence Q
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

5) chain A
residue 264
type
sequence S
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

6) chain A
residue 290
type
sequence S
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

7) chain A
residue 312
type
sequence W
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

8) chain A
residue 313
type
sequence V
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

9) chain A
residue 315
type
sequence Q
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

10) chain A
residue 328
type
sequence H
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

11) chain A
residue 330
type
sequence G
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

12) chain A
residue 331
type
sequence M
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

13) chain A
residue 332
type
sequence G
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

14) chain A
residue 333
type
sequence S
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

15) chain A
residue 336
type
sequence E
description BINDING SITE FOR RESIDUE UDP A1424
source : AC1

16) chain A
residue 25
type
sequence H
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

17) chain A
residue 79
type
sequence W
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

18) chain A
residue 80
type
sequence P
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

19) chain A
residue 83
type
sequence Q
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

20) chain A
residue 86
type
sequence A
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

21) chain A
residue 87
type
sequence M
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

22) chain A
residue 90
type
sequence F
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

23) chain A
residue 117
type
sequence I
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

24) chain A
residue 120
type
sequence W
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

25) chain A
residue 139
type
sequence T
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

26) chain A
residue 140
type
sequence F
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

27) chain A
residue 146
type
sequence F
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

28) chain A
residue 153
type
sequence V
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

29) chain A
residue 207
type
sequence L
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

30) chain A
residue 265
type
sequence A
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

31) chain A
residue 351
type
sequence A
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

32) chain A
residue 352
type
sequence E
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

33) chain A
residue 355
type
sequence M
description BINDING SITE FOR RESIDUE ZIO A1425
source : AC2

34) chain A
residue 312-353
type prosite
sequence WVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIA
EQ
description UDPGT UDP-glycosyltransferases signature. WvpQldILtkas..AFITHAGmgStmeALsnav.PMvavPqiaEQ
source prosite : PS00375


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