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eF-site ID
|
2iw8-B |
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PDB Code
|
2iw8 |
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Chain
|
B |
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click to enlarge
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Title
|
STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR |
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Classification
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CELL CYCLE |
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Compound
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CELL DIVISION PROTEIN KINASE 2 |
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Source
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Homo sapiens (Human) (CCNA2_HUMAN) |
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Sequence
|
B: |
PDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILV
DWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL
VGTAAMLLASKFEEIYPPEVAEFVYITTYTKKQVLRMEHL
VLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLG
ELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLI
RKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSK
YHGVSLLNPPETLNL
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
189 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE SGM B1433
|
| source |
: AC3
|
|
|
2)
|
chain |
B |
| residue |
193 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE SGM B1433
|
| source |
: AC3
|
|
|
3)
|
chain |
B |
| residue |
241 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE SGM B1433
|
| source |
: AC3
|
|
|
4)
|
chain |
B |
| residue |
305 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE SGM B1433
|
| source |
: AC3
|
|
|
5)
|
chain |
B |
| residue |
211-242 |
| type |
prosite |
| sequence |
RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
|
| description |
CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
|
| source |
prosite : PS00292
|
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