eF-site ID 2is1-ABCDEF PDB Code 2is1 Chain A, B, C, D, E, F click to enlarge Title Crystal structure of UvrD-DNA-SO4 complex Classification HYDROLASE/DNA Compound 5'-D(*GP*CP*AP*GP*TP*GP*CP*TP*CP*GP*TP*TP*TP*TP*TP*TP*T)-3' Source Escherichia coli (strain K12) (2IS1) Sequence A:  DVSYLLDSLNDKQREAVAAPRSNLLVLAGAGSGKTRVLVH RIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIGQLMGTS QGGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQLR LLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQS YGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWL NKPHILQHYRERFTNILVDEFQDTNNIQYAWIRLLAGDTG KVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQ NYRSTSNILSAANALIENNNGRLGKKLWTDGADGEPISLY CAFNELDEARFVVNRIKTWQDNGGALAECAILYRSNAQSR VLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIVNR NDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQAC RELLQEKALAGRAASALQRFMELIDALAQETADMPLHVQT DRVIKDSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSY NEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMTLHSAKG LEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVT RAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPEECVEEV RLRATVSRP B:  VSYLLDSLNDKQREAVAAPRSNLLVLAGAGSGKTRVLVHR IAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIGQLMGTSQ GGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQLRL LKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQSV EQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHI LQHYRERFTNILVDEFQDTNNIQYAWIRLLAGDTGKVMIV GDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRST SNILSAANALIENNNGRLGKKLWTDGADGEPISLYCAFNE LDEARFVVNRIKTWQDNGGALAECAILYRSNAQSRVLEEA LLQASMPYRIYGGMRFFERQEIKDALSYLRLIVNRNDDAA FERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQACRELLQ EKALAGRAASALQRFMELIDALAQETADMPLHVQTDRVIK DSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSYDEDLM PLQAFLSHAALEAGEGQDAVQLMTLHSAKGLEFPQVFIVG MEEGMFPSQMRLEEERRLAYVGVTRAMQKLTLTYAETRRL YGKEVYHRPSRFIGELPEECVEEV C:  GCAGTGCTCGTTTTTT D:  CGAGCACTGC E:  GCAGTGCTCGTTTTT F:  CGAGCACTGC Description Functional site 1) chain A residue 322 type sequence C description BINDING SITE FOR RESIDUE HG A 681 source : AC1 2) chain A residue 323 type sequence A description BINDING SITE FOR RESIDUE HG A 681 source : AC1 3) chain A residue 616 type sequence E description BINDING SITE FOR RESIDUE HG A 681 source : AC1 4) chain A residue 645 type sequence R description BINDING SITE FOR RESIDUE HG A 681 source : AC1 5) chain A residue 288 type sequence N description BINDING SITE FOR RESIDUE HG A 682 source : AC2 6) chain A residue 640 type sequence C description BINDING SITE FOR RESIDUE HG A 682 source : AC2 7) chain A residue 22 type sequence R description BINDING SITE FOR RESIDUE HG A 683 source : AC3 8) chain A residue 52 type sequence C description BINDING SITE FOR RESIDUE HG A 683 source : AC3 9) chain B residue 322 type sequence C description BINDING SITE FOR RESIDUE HG B 681 source : AC4 10) chain B residue 323 type sequence A description BINDING SITE FOR RESIDUE HG B 681 source : AC4 11) chain B residue 288 type sequence N description BINDING SITE FOR RESIDUE HG B 682 source : AC5 12) chain B residue 640 type sequence C description BINDING SITE FOR RESIDUE HG B 682 source : AC5 13) chain A residue 31 type sequence A description BINDING SITE FOR RESIDUE SO4 A 684 source : AC6 14) chain A residue 251 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 684 source : AC6 15) chain A residue 284 type sequence R description BINDING SITE FOR RESIDUE SO4 A 684 source : AC6 16) chain A residue 564 type sequence G description BINDING SITE FOR RESIDUE SO4 A 684 source : AC6 17) chain A residue 605 type sequence R description BINDING SITE FOR RESIDUE SO4 A 684 source : AC6 18) chain B residue 31 type sequence A description BINDING SITE FOR RESIDUE SO4 B 683 source : AC7 19) chain B residue 251 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 683 source : AC7 20) chain B residue 284 type sequence R description BINDING SITE FOR RESIDUE SO4 B 683 source : AC7 21) chain B residue 605 type sequence R description BINDING SITE FOR RESIDUE SO4 B 683 source : AC7 22) chain A residue 34 type sequence G description BINDING SITE FOR RESIDUE SO4 A 685 source : AC8 23) chain A residue 36 type sequence T description BINDING SITE FOR RESIDUE SO4 A 685 source : AC8 24) chain A residue 37 type sequence R description BINDING SITE FOR RESIDUE SO4 A 685 source : AC8 25) chain A residue 73 type sequence R description BINDING SITE FOR RESIDUE SO4 A 685 source : AC8 26) chain A residue 35 type sequence K description BINDING SITE FOR RESIDUE GOL A 686 source : AC9 27) chain A residue 36 type sequence T description BINDING SITE FOR RESIDUE GOL A 686 source : AC9 28) chain A residue 69 type sequence E description BINDING SITE FOR RESIDUE GOL A 686 source : AC9 29) chain B residue 34 type sequence G description BINDING SITE FOR RESIDUE GOL B 684 source : BC1 30) chain B residue 36 type sequence T description BINDING SITE FOR RESIDUE GOL B 684 source : BC1 31) chain B residue 37 type sequence R description BINDING SITE FOR RESIDUE GOL B 684 source : BC1 32) chain B residue 73 type sequence R description BINDING SITE FOR RESIDUE GOL B 684 source : BC1 33) chain A residue 32 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00560 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 32 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00560 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 284 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 284 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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