eF-site ID 2ipf-B
PDB Code 2ipf
Chain B

click to enlarge
Title Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone
Classification OXIDOREDUCTASE
Compound (3(17)alpha-hydroxysteroid dehydrogenase)
Source (Q9CX32_MOUSE)
Sequence B:  HCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAG
FHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKV
WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPG
EENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGV
SNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDF
CKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMA
KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFE
FQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY
Description


Functional site

1) chain B
residue 22
type
sequence G
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

2) chain B
residue 23
type
sequence T
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

3) chain B
residue 24
type
sequence A
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

4) chain B
residue 50
type
sequence D
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

5) chain B
residue 55
type
sequence Y
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

6) chain B
residue 84
type
sequence K
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

7) chain B
residue 117
type
sequence H
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

8) chain B
residue 166
type
sequence S
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

9) chain B
residue 167
type
sequence N
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

10) chain B
residue 190
type
sequence Q
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

11) chain B
residue 216
type
sequence Y
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

12) chain B
residue 217
type
sequence G
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

13) chain B
residue 218
type
sequence V
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

14) chain B
residue 219
type
sequence L
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

15) chain B
residue 220
type
sequence G
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

16) chain B
residue 221
type
sequence T
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

17) chain B
residue 222
type
sequence Q
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

18) chain B
residue 224
type
sequence Y
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

19) chain B
residue 236
type
sequence L
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

20) chain B
residue 253
type
sequence A
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

21) chain B
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

22) chain B
residue 270
type
sequence T
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

23) chain B
residue 271
type
sequence S
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

24) chain B
residue 272
type
sequence L
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

25) chain B
residue 273
type
sequence K
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

26) chain B
residue 276
type
sequence R
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

27) chain B
residue 279
type
sequence E
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

28) chain B
residue 280
type
sequence N
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

29) chain B
residue 306
type
sequence I
description BINDING SITE FOR RESIDUE NAP B 2
source : AC2

30) chain B
residue 25
type
sequence L
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

31) chain B
residue 31
type
sequence K
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

32) chain B
residue 55
type
sequence Y
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

33) chain B
residue 117
type
sequence H
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

34) chain B
residue 118
type
sequence Y
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

35) chain B
residue 129
type
sequence F
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

36) chain B
residue 224
type
sequence Y
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

37) chain B
residue 227
type
sequence W
description BINDING SITE FOR RESIDUE FFA B 4
source : AC4

38) chain B
residue 29
type
sequence C
description BINDING SITE FOR RESIDUE BME B 324
source : AC7

39) chain B
residue 145
type
sequence C
description BINDING SITE FOR RESIDUE BME B 325
source : AC8

40) chain B
residue 6
type
sequence H
description BINDING SITE FOR RESIDUE BME B 326
source : BC1

41) chain B
residue 7
type
sequence C
description BINDING SITE FOR RESIDUE BME B 326
source : BC1

42) chain B
residue 287
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 326
source : BC2

43) chain B
residue 6
type
sequence H
description BINDING SITE FOR RESIDUE EDO B 327
source : BC4

44) chain B
residue 17
type
sequence P
description BINDING SITE FOR RESIDUE EDO B 327
source : BC4

45) chain B
residue 18
type
sequence V
description BINDING SITE FOR RESIDUE EDO B 327
source : BC4

46) chain B
residue 19
type
sequence L
description BINDING SITE FOR RESIDUE EDO B 327
source : BC4

47) chain B
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE EDO B 327
source : BC4

48) chain B
residue 284
type
sequence F
description BINDING SITE FOR RESIDUE EDO B 327
source : BC4

49) chain B
residue 55
type ACT_SITE
sequence Y
description Proton donor
source Swiss-Prot : SWS_FT_FI1

50) chain B
residue 190
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748
source Swiss-Prot : SWS_FT_FI2

51) chain B
residue 216
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748
source Swiss-Prot : SWS_FT_FI2

52) chain B
residue 270
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748
source Swiss-Prot : SWS_FT_FI2

53) chain B
residue 20
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748
source Swiss-Prot : SWS_FT_FI2

54) chain B
residue 50
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748
source Swiss-Prot : SWS_FT_FI2

55) chain B
residue 166
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748
source Swiss-Prot : SWS_FT_FI2

56) chain B
residue 31
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

57) chain B
residue 117
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI3

58) chain B
residue 84
type SITE
sequence K
description Lowers pKa of active site Tyr => ECO:0000250
source Swiss-Prot : SWS_FT_FI4


Display surface

Download
Links