eF-site ID 2ipf-A PDB Code 2ipf Chain A click to enlarge Title Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone Classification OXIDOREDUCTASE Compound (3(17)alpha-hydroxysteroid dehydrogenase) Source (Q9CX32_MOUSE) Sequence A:  HCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAG FHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKV WCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPG EENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGV SNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDF CKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMA KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFE FQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY Description Functional site 1) chain A residue 22 type sequence G description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 2) chain A residue 23 type sequence T description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 3) chain A residue 24 type sequence A description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 4) chain A residue 50 type sequence D description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 5) chain A residue 55 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 6) chain A residue 84 type sequence K description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 7) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 8) chain A residue 166 type sequence S description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 9) chain A residue 167 type sequence N description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 10) chain A residue 190 type sequence Q description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 11) chain A residue 216 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 12) chain A residue 217 type sequence G description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 13) chain A residue 218 type sequence V description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 14) chain A residue 219 type sequence L description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 15) chain A residue 220 type sequence G description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 16) chain A residue 221 type sequence T description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 17) chain A residue 222 type sequence Q description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 18) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 19) chain A residue 236 type sequence L description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 20) chain A residue 253 type sequence A description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 21) chain A residue 269 type sequence N description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 22) chain A residue 270 type sequence T description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 23) chain A residue 271 type sequence S description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 24) chain A residue 272 type sequence L description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 25) chain A residue 273 type sequence K description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 26) chain A residue 276 type sequence R description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 27) chain A residue 279 type sequence E description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 28) chain A residue 280 type sequence N description BINDING SITE FOR RESIDUE NAP A 1 source : AC1 29) chain A residue 25 type sequence L description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 30) chain A residue 27 type sequence L description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 31) chain A residue 31 type sequence K description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 32) chain A residue 55 type sequence Y description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 33) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 34) chain A residue 118 type sequence Y description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 35) chain A residue 129 type sequence F description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 36) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 37) chain A residue 227 type sequence W description BINDING SITE FOR RESIDUE FFA A 3 source : AC3 38) chain A residue 29 type sequence C description BINDING SITE FOR RESIDUE BME A 5 source : AC5 39) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE BME A 324 source : AC6 40) chain A residue 7 type sequence C description BINDING SITE FOR RESIDUE BME A 325 source : AC9 41) chain A residue 78 type sequence D description BINDING SITE FOR RESIDUE BME A 325 source : AC9 42) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE EDO A 326 source : BC2 43) chain A residue 210 type sequence D description BINDING SITE FOR RESIDUE EDO A 326 source : BC2 44) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE EDO A 327 source : BC3 45) chain A residue 184 type sequence Y description BINDING SITE FOR RESIDUE EDO A 327 source : BC3 46) chain A residue 185 type sequence K description BINDING SITE FOR RESIDUE EDO A 327 source : BC3 47) chain A residue 15 type sequence F description BINDING SITE FOR RESIDUE TRS A 328 source : BC5 48) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE TRS A 328 source : BC5 49) chain A residue 80 type sequence F description BINDING SITE FOR RESIDUE TRS A 328 source : BC5 50) chain A residue 112 type sequence D description BINDING SITE FOR RESIDUE TRS A 328 source : BC5 51) chain A residue 161 type sequence K description BINDING SITE FOR RESIDUE TRS A 328 source : BC5 52) chain A residue 55 type ACT_SITE sequence Y description Proton donor source Swiss-Prot : SWS_FT_FI1 53) chain A residue 84 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 54) chain A residue 151-168 type prosite sequence MEKCKDAGLTKSIGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MekckdaglTKSIGVSNF source prosite : PS00062 55) chain A residue 20 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 50 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 57) chain A residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 58) chain A residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 59) chain A residue 216 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 270 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 31 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 62) chain A residue 117 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI3

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