eF-site ID 2iik-A PDB Code 2iik Chain A click to enlarge Title Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1) Classification TRANSFERASE Compound 3-ketoacyl-CoA thiolase, peroxisomal Source Homo sapiens (Human) (THIK_HUMAN) Sequence A:  ASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAV LKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPE TVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVES MSLADGNITSRLMEKEKARDCLIPMGITSENVAERFGISR EKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGT KRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSS QVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDI MGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCV EKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKR RGKRAYGVVSMCIGTGMGAAAVFEYP Description Functional site 1) chain A residue 125 type ACT_SITE sequence S description Acyl-thioester intermediate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 380 type ACT_SITE sequence L description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 411 type ACT_SITE sequence G description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 61 type MOD_RES sequence P description Phosphothreonine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI3 5) chain A residue 62 type MOD_RES sequence D description Phosphothreonine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 119-137 type prosite sequence VNRQCSSGLQAVASIAGGI description THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNRqCSSGLqAVasiaggI source prosite : PS00098 7) chain A residue 404-417 type prosite sequence GVVSMCIGTGMGAA description THIOLASE_3 Thiolases active site. GVVSMCIGtGmGaA source prosite : PS00099 8) chain A residue 368-384 type prosite sequence NPLGGAVALGHPLGCTG description THIOLASE_2 Thiolases signature 2. NplGGaVAlGHPlGcTG source prosite : PS00737

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