eF-site ID 2igx-A PDB Code 2igx Chain A click to enlarge Title Achiral, Cheap and Potent Inhibitors of Plasmepsins II Classification HYDROLASE Compound Plasmepsin-2 Source ORGANISM_COMMON: malaria parasite P. falciparum; ORGANISM_SCIENTIFIC: Plasmodium falciparum; Sequence A:  SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANL WVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSG TVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTF DGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPV HDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAH VGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVP FLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDV GPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSV GIALAKKNL Description (1)  Plasmepsin-2 (E.C.3.4.23.39) Functional site 1) chain A residue 14 type sequence I description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 2) chain A residue 15 type sequence M description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 3) chain A residue 17 type sequence Y description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 4) chain A residue 32 type sequence I description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 5) chain A residue 34 type sequence D description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 6) chain A residue 36 type sequence G description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 7) chain A residue 41 type sequence W description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 8) chain A residue 77 type sequence Y description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 9) chain A residue 111 type sequence F description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 10) chain A residue 114 type sequence T description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 11) chain A residue 115 type sequence Y description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 12) chain A residue 118 type sequence S description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 13) chain A residue 120 type sequence F description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 14) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 15) chain A residue 123 type sequence I description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 16) chain A residue 192 type sequence Y description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 17) chain A residue 214 type sequence D description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 18) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 19) chain A residue 239 type sequence V description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 20) chain A residue 280 type sequence V description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 21) chain A residue 284 type sequence L description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 22) chain A residue 294 type sequence F description BINDING SITE FOR RESIDUE A1T A 330 source : AC1 23) chain A residue 34 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 214 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 31-42 type prosite sequence FILDTGSANLWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FILDTGSANLWV source prosite : PS00141 26) chain A residue 211-222 type prosite sequence CIVDSGTSAITV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FILDTGSANLWV source prosite : PS00141

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