eF-site ID 2ifg-ABEF PDB Code 2ifg Chain A, B, E, F click to enlarge Title Structure of the extracellular segment of human TRKA in complex with nerve growth factor Classification TRANSFERASE Compound High affinity nerve growth factor receptor Source (NGF_HUMAN) Sequence A:  CPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIEN QQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTP RLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCA LRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPT LKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQS ATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAE VSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRW LFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVN NGNYTLLAANPFGQASASIMAAFMDNP B:  CPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIEN QQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTP RLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCA LRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPT LKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQS ATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAE VSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRW LFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVN NGNYTLLAANPFGQASASIMAAFMDNP E:  SSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGE VNINNSVFKQYFFETKCRDGCRGIDSKHWNSYCTTTHTFV KALTMDGKQAAWRFIRIDTACVCVLSRK F:  SSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGE VNINNSVFKQYFFETKCRDGCRGIDSKHWNSYCTTTHTFV KALTMDGKQAAWRFIRIDTACVCVLSRKA Description Functional site 1) chain A residue 188 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 2) chain A residue 262 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 3) chain A residue 281 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 4) chain A residue 358 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 5) chain B residue 188 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 6) chain B residue 262 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 7) chain B residue 281 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 8) chain B residue 358 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG source Swiss-Prot : SWS_FT_FI3 9) chain E residue 88 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI2 10) chain F residue 88 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 95 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 121 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI2 13) chain E residue 67-80 type prosite sequence GCRGIDSKHWNSYC description NGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC source prosite : PS00248 14) chain E residue 52 type BINDING sequence Y description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 318 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 323 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 338 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 18) chain F residue 52 type BINDING sequence Y description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 253 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 318 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 323 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 338 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 67 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 202 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 253 type BINDING sequence N description in other chain => ECO:0000250|UniProtKB:P01139 source Swiss-Prot : SWS_FT_FI1

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