eF-site ID 2ieh-B PDB Code 2ieh Chain B click to enlarge Title Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer Classification HYDROLASE Compound Kinesin-like protein KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence B:  GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTG GLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIM GYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGI IPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPS SDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILE KGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEEL VKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPY RESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLE YAHRAKNILNKPEVN Description Functional site 1) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 604 source : AC4 2) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 3) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 4) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 5) chain B residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 6) chain B residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 7) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 8) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 9) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 10) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 11) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 12) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 13) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 14) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 15) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 16) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 17) chain B residue 119 type sequence R description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 18) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 19) chain B residue 133 type sequence A description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 20) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 21) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 22) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 23) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 24) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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