eF-site ID 2ieh-AB PDB Code 2ieh Chain A, B click to enlarge Title Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer Classification HYDROLASE Compound Kinesin-like protein KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence A:  KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRT GGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVI MGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAG IIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNP SSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQIL EKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEE LVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVP YRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTL EYAHRAKNILNKPE B:  GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTG GLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIM GYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGI IPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPS SDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILE KGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEEL VKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPY RESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLE YAHRAKNILNKPEVN Description Functional site 1) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE MG A 601 source : AC1 2) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE K A 607 source : AC2 3) chain A residue 25 type sequence C description BINDING SITE FOR RESIDUE K A 607 source : AC2 4) chain A residue 73 type sequence G description BINDING SITE FOR RESIDUE K A 607 source : AC2 5) chain A residue 74 type sequence A description BINDING SITE FOR RESIDUE K A 607 source : AC2 6) chain A residue 76 type sequence T description BINDING SITE FOR RESIDUE K A 607 source : AC2 7) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE CL A 608 source : AC3 8) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 604 source : AC4 9) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 10) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 11) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 12) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 13) chain A residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 14) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 15) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 16) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 17) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 18) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 19) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 20) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP A 600 source : AC5 21) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 22) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 23) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 24) chain A residue 119 type sequence R description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 25) chain A residue 127 type sequence W description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 26) chain A residue 130 type sequence D description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 27) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 28) chain A residue 137 type sequence P description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 29) chain A residue 160 type sequence L description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 30) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 31) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 32) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE MOY A 602 source : AC6 33) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 34) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 35) chain A residue 74 type sequence A description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 36) chain A residue 76 type sequence T description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 37) chain A residue 77 type sequence K description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 38) chain A residue 78 type sequence Q description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 39) chain A residue 79 type sequence I description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 40) chain A residue 131 type sequence P description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 41) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE PG4 A 606 source : AC7 42) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 43) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 44) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 45) chain B residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 46) chain B residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 47) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 48) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 49) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 50) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 51) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 52) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 53) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 603 source : AC8 54) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 55) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 56) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 57) chain B residue 119 type sequence R description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 58) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 59) chain B residue 133 type sequence A description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 60) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 61) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 62) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 63) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE MOY B 605 source : AC9 64) chain A residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 68) chain A residue 259-270 type prosite sequence GKLNLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE source prosite : PS00411

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