eF-site ID 2idw-B PDB Code 2idw Chain B click to enlarge Title Crystal structure analysis of HIV-1 protease mutant V82A with a potent non-peptide inhibitor (UIC-94017) Classification HYDROLASE Compound Protease Source (POL_HV1PV) Sequence B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PANIIGRNLLTQIGATLNF Description Functional site 1) chain B residue 114 type sequence K description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 2) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 3) chain B residue 136 type sequence M description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 4) chain B residue 137 type sequence S description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 5) chain B residue 101 type sequence P description BINDING SITE FOR RESIDUE PO4 B 703 source : AC4 6) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE PO4 B 703 source : AC4 7) chain B residue 169 type sequence H description BINDING SITE FOR RESIDUE PO4 B 703 source : AC4 8) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 9) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 10) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 11) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 12) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 13) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 14) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 15) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 16) chain B residue 168 type sequence G description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 17) chain B residue 169 type sequence H description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 18) chain B residue 170 type sequence K description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 19) chain B residue 139 type sequence P description BINDING SITE FOR RESIDUE ACY A 601 source : AC8 20) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE ACY B 602 source : AC9 21) chain B residue 191 type sequence T description BINDING SITE FOR RESIDUE ACY B 603 source : BC1 22) chain B residue 194 type sequence G description BINDING SITE FOR RESIDUE ACY B 603 source : BC1 23) chain B residue 110 type sequence L description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 24) chain B residue 111 type sequence V description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 25) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 26) chain B residue 121 type sequence E description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 27) chain B residue 114 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 28) chain B residue 155 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 29) chain B residue 165 type sequence E description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 30) chain B residue 126 type ACT_SITE sequence T description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 101 type SITE sequence P description Cleavage; by viral protease source Swiss-Prot : SWS_FT_FI2

Display surface Download Links