eF-site ID 2idw-AB PDB Code 2idw Chain A, B click to enlarge Title Crystal structure analysis of HIV-1 protease mutant V82A with a potent non-peptide inhibitor (UIC-94017) Classification HYDROLASE Compound Protease Source (POL_HV1PV) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PANIIGRNLLTQIGATLNF B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PANIIGRNLLTQIGATLNF Description Functional site 1) chain A residue 73 type sequence G description BINDING SITE FOR RESIDUE CL A 501 source : AC1 2) chain A residue 74 type sequence T description BINDING SITE FOR RESIDUE CL A 501 source : AC1 3) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE CL A 501 source : AC1 4) chain A residue 14 type sequence K description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 5) chain A residue 15 type sequence I description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 6) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 7) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 8) chain B residue 114 type sequence K description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 9) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 10) chain A residue 39 type sequence P description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 11) chain A residue 40 type sequence G description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 12) chain B residue 136 type sequence M description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 13) chain B residue 137 type sequence S description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 14) chain B residue 101 type sequence P description BINDING SITE FOR RESIDUE PO4 B 703 source : AC4 15) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE PO4 B 703 source : AC4 16) chain B residue 169 type sequence H description BINDING SITE FOR RESIDUE PO4 B 703 source : AC4 17) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 18) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 19) chain A residue 34 type sequence E description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 20) chain A residue 41 type sequence R description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 21) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 22) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 23) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 24) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 25) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 26) chain A residue 32 type sequence V description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 27) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 28) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 29) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 30) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 31) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 32) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 33) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 34) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 35) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 36) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 37) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 38) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 39) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 40) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 41) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 42) chain B residue 168 type sequence G description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 43) chain B residue 169 type sequence H description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 44) chain B residue 170 type sequence K description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 45) chain A residue 36 type sequence M description BINDING SITE FOR RESIDUE ACY A 601 source : AC8 46) chain A residue 37 type sequence S description BINDING SITE FOR RESIDUE ACY A 601 source : AC8 47) chain B residue 139 type sequence P description BINDING SITE FOR RESIDUE ACY A 601 source : AC8 48) chain A residue 92 type sequence Q description BINDING SITE FOR RESIDUE ACY B 602 source : AC9 49) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE ACY B 602 source : AC9 50) chain A residue 6 type sequence W description BINDING SITE FOR RESIDUE ACY B 603 source : BC1 51) chain B residue 191 type sequence T description BINDING SITE FOR RESIDUE ACY B 603 source : BC1 52) chain B residue 194 type sequence G description BINDING SITE FOR RESIDUE ACY B 603 source : BC1 53) chain B residue 110 type sequence L description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 54) chain B residue 111 type sequence V description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 55) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 56) chain B residue 121 type sequence E description BINDING SITE FOR RESIDUE ACY B 604 source : BC2 57) chain A residue 46 type sequence M description BINDING SITE FOR RESIDUE ACY A 605 source : BC3 58) chain A residue 53 type sequence F description BINDING SITE FOR RESIDUE ACY A 605 source : BC3 59) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE ACY A 605 source : BC3 60) chain A residue 14 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 61) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 62) chain B residue 114 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 63) chain B residue 155 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 64) chain B residue 165 type sequence E description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 65) chain A residue 42 type sequence W description BINDING SITE FOR RESIDUE GOL A 801 source : BC5 66) chain A residue 44 type sequence P description BINDING SITE FOR RESIDUE GOL A 801 source : BC5 67) chain A residue 56 type sequence V description BINDING SITE FOR RESIDUE GOL A 801 source : BC5 68) chain A residue 1 type SITE sequence P description Cleavage; by viral protease source Swiss-Prot : SWS_FT_FI2 69) chain B residue 101 type SITE sequence P description Cleavage; by viral protease source Swiss-Prot : SWS_FT_FI2 70) chain A residue 26 type ACT_SITE sequence T description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 71) chain B residue 126 type ACT_SITE sequence T description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 72) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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