eF-site ID 2idw-A PDB Code 2idw Chain A click to enlarge Title Crystal structure analysis of HIV-1 protease mutant V82A with a potent non-peptide inhibitor (UIC-94017) Classification HYDROLASE Compound Protease Source (POL_HV1PV) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PANIIGRNLLTQIGATLNF Description Functional site 1) chain A residue 73 type sequence G description BINDING SITE FOR RESIDUE CL A 501 source : AC1 2) chain A residue 74 type sequence T description BINDING SITE FOR RESIDUE CL A 501 source : AC1 3) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE CL A 501 source : AC1 4) chain A residue 14 type sequence K description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 5) chain A residue 15 type sequence I description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 6) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 7) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 A 701 source : AC2 8) chain A residue 39 type sequence P description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 9) chain A residue 40 type sequence G description BINDING SITE FOR RESIDUE PO4 A 702 source : AC3 10) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 11) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 12) chain A residue 34 type sequence E description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 13) chain A residue 41 type sequence R description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 14) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 A 704 source : AC5 15) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 16) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 17) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 18) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 19) chain A residue 32 type sequence V description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 20) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 21) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 22) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 23) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 24) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE 017 B 401 source : AC6 25) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 26) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE DMS A 901 source : AC7 27) chain A residue 36 type sequence M description BINDING SITE FOR RESIDUE ACY A 601 source : AC8 28) chain A residue 37 type sequence S description BINDING SITE FOR RESIDUE ACY A 601 source : AC8 29) chain A residue 92 type sequence Q description BINDING SITE FOR RESIDUE ACY B 602 source : AC9 30) chain A residue 6 type sequence W description BINDING SITE FOR RESIDUE ACY B 603 source : BC1 31) chain A residue 46 type sequence M description BINDING SITE FOR RESIDUE ACY A 605 source : BC3 32) chain A residue 53 type sequence F description BINDING SITE FOR RESIDUE ACY A 605 source : BC3 33) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE ACY A 605 source : BC3 34) chain A residue 14 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 35) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE ACY B 606 source : BC4 36) chain A residue 42 type sequence W description BINDING SITE FOR RESIDUE GOL A 801 source : BC5 37) chain A residue 44 type sequence P description BINDING SITE FOR RESIDUE GOL A 801 source : BC5 38) chain A residue 56 type sequence V description BINDING SITE FOR RESIDUE GOL A 801 source : BC5 39) chain A residue 1 type SITE sequence P description Cleavage; by viral protease source Swiss-Prot : SWS_FT_FI2 40) chain A residue 26 type ACT_SITE sequence T description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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