eF-site ID 2i1y-AB PDB Code 2i1y Chain A, B click to enlarge Title Crystal structure of the phosphatase domain of human PTP IA-2 Classification HYDROLASE Compound Receptor-type tyrosine-protein phosphatase Source (PTPRN_HUMAN) Sequence A:  TGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQ GEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPI IEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLT PLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFL VRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDF RRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMA KGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV NAILKAL B:  MDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTC ATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYIN ASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVI VMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWC EDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRP LLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVL NRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAV AEEVNAILKA Description Functional site 1) chain A residue 926 type sequence L description BINDING SITE FOR RESIDUE GOL A 3288 source : AC1 2) chain A residue 929 type sequence M description BINDING SITE FOR RESIDUE GOL A 3288 source : AC1 3) chain A residue 930 type sequence A description BINDING SITE FOR RESIDUE GOL A 3288 source : AC1 4) chain A residue 973 type sequence I description BINDING SITE FOR RESIDUE GOL A 3288 source : AC1 5) chain B residue 926 type sequence L description BINDING SITE FOR RESIDUE GOL B 3287 source : AC2 6) chain B residue 929 type sequence M description BINDING SITE FOR RESIDUE GOL B 3287 source : AC2 7) chain B residue 970 type sequence V description BINDING SITE FOR RESIDUE GOL B 3287 source : AC2 8) chain B residue 973 type sequence I description BINDING SITE FOR RESIDUE GOL B 3287 source : AC2 9) chain A residue 754 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16622421 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 754 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16622421 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 907-917 type prosite sequence VHCSDGAGRTG description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsdGagRTG source prosite : PS00383

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