eF-site ID 2hx2-B PDB Code 2hx2 Chain B click to enlarge Title Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine Classification OXIDOREDUCTASE Compound Nitric-oxide synthase Source null (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVA STGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDA RDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHG WTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHP TLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKA AVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKAR GGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD PW Description Functional site 1) chain B residue 69 type sequence K description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 2) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 3) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 4) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 5) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 6) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 7) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 8) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 9) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 861 source : AC6 10) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 861 source : AC6 11) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 861 source : AC6 12) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 13) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 14) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 15) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 16) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 17) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 18) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 19) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 20) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 21) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 22) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 23) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 24) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 25) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 26) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 27) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 28) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 29) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 30) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 31) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 32) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 33) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 34) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 35) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 36) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 37) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 38) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 39) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 40) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 41) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 42) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 43) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 44) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 45) chain B residue 187 type BINDING sequence V description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 46) chain B residue 97 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 47) chain B residue 102 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 48) chain B residue 105 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 250 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 360 type BINDING sequence M description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 364 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 369 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 450 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 463 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2

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