eF-site ID 2hx2-AB PDB Code 2hx2 Chain A, B click to enlarge Title Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine Classification OXIDOREDUCTASE Compound Nitric-oxide synthase Source null (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEV ASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFD ARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPG RGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQH GWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEH PTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWY MSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDK AAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKA RGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQP DPW B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVA STGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDA RDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHG WTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHP TLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKA AVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKAR GGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD PW Description Functional site 1) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC A 850 source : AC1 2) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC A 850 source : AC1 3) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 4) chain A residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 5) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 6) chain A residue 249 type sequence Q description BINDING SITE FOR RESIDUE ACT A 861 source : AC3 7) chain A residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT A 861 source : AC3 8) chain A residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT A 861 source : AC3 9) chain A residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT A 861 source : AC3 10) chain B residue 69 type sequence K description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 11) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 12) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 13) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAC B 850 source : AC4 14) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 15) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 16) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 17) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 860 source : AC5 18) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE ACT B 861 source : AC6 19) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE ACT B 861 source : AC6 20) chain B residue 374 type sequence R description BINDING SITE FOR RESIDUE ACT B 861 source : AC6 21) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 22) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 23) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 24) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC7 25) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 26) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 27) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 28) chain A residue 341 type sequence M description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 29) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 30) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 31) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 32) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 33) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 34) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 700 source : AC8 35) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 36) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 37) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 38) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 39) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 40) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 41) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 42) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 43) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC9 44) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 45) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 46) chain A residue 340 type sequence N description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 47) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 48) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 49) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 50) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 51) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE 3HX A 793 source : BC1 52) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 53) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 54) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 55) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 56) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 57) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 58) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 59) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 60) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 61) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 62) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 700 source : BC2 63) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 64) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 65) chain A residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 66) chain A residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 67) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 68) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 69) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 70) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 760 source : BC3 71) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 72) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 73) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 74) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 75) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 76) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 77) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE 3HX B 793 source : BC4 78) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 79) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 80) chain A residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL A 880 source : BC5 81) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 82) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 83) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 84) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 85) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : BC6 86) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 87) chain A residue 187 type BINDING sequence V description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 88) chain B residue 187 type BINDING sequence V description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 89) chain A residue 97 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 102 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 91) chain B residue 97 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 102 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 105 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 250 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 360 type BINDING sequence M description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 364 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 369 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 101) chain B residue 450 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 102) chain B residue 463 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 103) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 360 type BINDING sequence M description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 364 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 107) chain A residue 369 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 108) chain A residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 109) chain A residue 450 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 110) chain A residue 463 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 111) chain A residue 105 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 112) chain A residue 250 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2

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