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|
eF-site ID
|
2hwr-B |
|
PDB Code
|
2hwr |
|
Chain
|
B |
|
click to enlarge
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Title
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Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists |
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Classification
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LIGAND BINDING PROTEIN |
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Compound
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Peroxisome proliferator-activated receptor gamma |
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Source
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Homo sapiens (Human) (PPARG_HUMAN) |
|
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Sequence
|
B: |
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP
FVIYDMNSLMMGEDKIQEQSKEVAIRIFQGCQFRSVEAVQ
EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLM
NKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKF
NALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL
QALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQ
VIKKTETDMSLHP
|
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
323 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
B |
| residue |
449 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
286 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
224 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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