eF-site ID 2hu4-H PDB Code 2hu4 Chain H click to enlarge Title N1 neuraminidase in complex with oseltamivir 2 Classification HYDROLASE Compound Neuraminidase Source ORGANISM_SCIENTIFIC: Influenza A virus; Sequence H:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS ISFCGVNSDTVGWSWPDGAELPFTI Description (1)  Neuraminidase Functional site 1) chain H residue 119 type sequence E description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 2) chain H residue 151 type sequence D description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 3) chain H residue 152 type sequence R description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 4) chain H residue 224 type sequence R description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 5) chain H residue 276 type sequence E description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 6) chain H residue 277 type sequence E description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 7) chain H residue 292 type sequence R description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 8) chain H residue 347 type sequence Y description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 9) chain H residue 371 type sequence R description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 10) chain H residue 406 type sequence Y description BINDING SITE FOR RESIDUE G39 H 807 source : AC8 11) chain H residue 151 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI1 12) chain H residue 406 type ACT_SITE sequence Y description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI2 13) chain H residue 118 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 14) chain H residue 152 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 15) chain H residue 276 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 16) chain H residue 292 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 17) chain H residue 371 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 18) chain H residue 293 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 19) chain H residue 297 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 20) chain H residue 324 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 21) chain H residue 345 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI5 22) chain H residue 347 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ source Swiss-Prot : SWS_FT_FI6

Display surface Download Links