eF-site ID 2hu4-F PDB Code 2hu4 Chain F click to enlarge Title N1 neuraminidase in complex with oseltamivir 2 Classification HYDROLASE Compound Neuraminidase Source ORGANISM_SCIENTIFIC: Influenza A virus; Sequence F:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS ISFCGVNSDTVGWSWPDGAELPFTI Description (1)  Neuraminidase Functional site 1) chain F residue 118 type sequence R description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 2) chain F residue 119 type sequence E description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 3) chain F residue 151 type sequence D description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 4) chain F residue 152 type sequence R description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 5) chain F residue 246 type sequence S description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 6) chain F residue 276 type sequence E description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 7) chain F residue 277 type sequence E description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 8) chain F residue 292 type sequence R description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 9) chain F residue 294 type sequence N description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 10) chain F residue 347 type sequence Y description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 11) chain F residue 371 type sequence R description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 12) chain F residue 406 type sequence Y description BINDING SITE FOR RESIDUE G39 F 805 source : AC6 13) chain F residue 151 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI1 14) chain F residue 406 type ACT_SITE sequence Y description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI2 15) chain F residue 118 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 16) chain F residue 152 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 17) chain F residue 276 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 18) chain F residue 292 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 19) chain F residue 371 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 20) chain F residue 293 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 21) chain F residue 297 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 22) chain F residue 324 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 23) chain F residue 345 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI5 24) chain F residue 347 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ source Swiss-Prot : SWS_FT_FI6

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