eF-site ID 2hu4-D
PDB Code 2hu4
Chain D

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Title N1 neuraminidase in complex with oseltamivir 2
Classification HYDROLASE
Compound Neuraminidase
Source ORGANISM_SCIENTIFIC: Influenza A virus;
Sequence D:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI
SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP
VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA
VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM
TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY
PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF
GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT
KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY
SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS
ISFCGVNSDTVGWSWPDGAELPFTI
Description (1)  Neuraminidase


Functional site

1) chain D
residue 118
type
sequence R
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

2) chain D
residue 119
type
sequence E
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

3) chain D
residue 151
type
sequence D
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

4) chain D
residue 152
type
sequence R
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

5) chain D
residue 224
type
sequence R
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

6) chain D
residue 246
type
sequence S
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

7) chain D
residue 276
type
sequence E
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

8) chain D
residue 292
type
sequence R
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

9) chain D
residue 347
type
sequence Y
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

10) chain D
residue 371
type
sequence R
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

11) chain D
residue 406
type
sequence Y
description BINDING SITE FOR RESIDUE G39 D 803
source : AC4

12) chain D
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1

13) chain D
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2

14) chain D
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

15) chain D
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

16) chain D
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

17) chain D
residue 292
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

18) chain D
residue 371
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3

19) chain D
residue 293
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4

20) chain D
residue 297
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4

21) chain D
residue 324
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4

22) chain D
residue 345
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI5

23) chain D
residue 347
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ
source Swiss-Prot : SWS_FT_FI6


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